Review Article

Detection and Management of Diabetes during Pregnancy in Low Resource Settings: Insights into Past and Present Clinical Practices

Table 1

Screening and management practices in identified publications.

NumberAuthor (ref.)YearCountrySettingDesignPopulationScreening(Re)admissionInpatient careFollow-upOutpatient careDeliveryNewborn carePostpartum

1Sutton [13]1977FijiReferral hospitalRetrospective observational21 pregnant diabetic women32 weeksBed rest, diet, glycaemia 2x weekly. Amniotic fluid 1x weekly at ≥36 weeks; steroids
1 week prenatal
Planned delivery at 38 weeks: vaginal delivery but CS if complications or labor >18 hours; observed CS rate 57%

2Fraser [14]1982KenyaNational hospitalRetrospective observational51 pregnant diabetic women50 g OGTTAfter first visit (<32 weeks); Readmission
32 weeks
Initial stay: diet,
glycaemia 3x/day
1-2/week;
readmission: urine & blood pressure daily; weight & uterine height weekly; ≥37 weeks: amniotic fluid weekly
Weekly or fortnightlyGlucose and urine, blood pressure, weight, and abdominal examinationInduction; CS if no delivery within 12 hrs or if indication;
observed CS rate 31% (half of them elective)
Pediatricians at delivery; observation of newborn for several days; early feeding

3Otolorin et al. [15]1985NigeriaUniversity hospitalRetrospective observational48 pregnant women diagnosed with diabetesInitial admission first trimester/after booking; readmission between 32–34 weeksDiet with 2000–2500 cal; twice weekly
4-point profile
Mode of delivery depending on several factors (e.g. age, diabetes control). Observed CS rate of 41%; 70% of patients delivered before 38 weeksAll newborn admitted to special newborn care unit and reviewed by pediatrician

4Lutale et al. [16]1991TanzaniaUniversity hospitalProspective observational47 pregnant diabetic womenNo specific policy; decision on individual basisEvery 2-3 weeks; weekly if poorly controlledGlucose and urine test, weight; no SMBGVaginal delivery; labor not routinely induced in uncomplicated pregnancies; induction only if shake test positive; observed CS rate 30%

5Kadiki et al. [17]1993LibyaUrban diabetes clinicRetrospective observational988 pregnant diabetic patientsHigh risk patients admitted at 34-35 weeks; all others in week 37-38Fortnightly until 24 weeks, weekly thereafterFasting and postprandial plasma glucose; no SMBG; ultrasound to monitor fetal growthVaginal delivery: induction of high risk patients in week 37-38; all others allowed to proceed to term; observed CS rate 36%

6Djanhan et al. [18]1995Ivory CoastUniversity hospitalProspective observational109 pregnant women diagnosed with diabetesInitially for 2 weeks; readmitted around termInitial stay: glycaemia, blood, and urine tests, vaginal swab, ophthalmological check, ultrasound, and diet counselling.
Readmission: FHB daily, every 2nd day fasting glucose
Weekly; obstetrician monthlyObservation: 95% delivered at term

7Akhter et al. [19]1996PakistanUniversity hospitalRetrospective observational267 diabetic pregnanciesUniversal screening: 50 g GCT weeks 20–28; women with RF/abnormal GCT: 75 g OGTTMonthly; fortnightly in third trimesterObserved CS rate: 26%

8Daponte et al. [20]1999South AfricaUniversity hospitalRetrospective observational142 pregnant women with diabetes100 g OGTTAdmission for education on glucose monitoring and diet6-point glucose profile daily, diet counselling (1800–2000 cal) & SMBG initiationWeekly by multidisciplinary teamWomen allowed to proceed to term if good glycemic control and no other obstetric complications; observed CS rate 49%; mean gestational age at delivery 38 weeks

9Mirghani and Saeed [21]2000SudanTeaching hospitalProspective observational74 pregnant women with diabetes75 g OGTTInitial admission; readmission weeks 34–36Initial admission: urine 6 hourly and glycaemia 2x/week;
readmission: FBG 2x/weekly
Fortnightly ANC: FBG
(no SMBG possible)
Delivery 38 weeks (induction or CS if not delivered within 12 hours), during labor glycosuria & glycaemia, prophylactic antibiotics. Observed CS rate 65%Breast feeding 30 min after delivery and 4–6 hours after CS. Pediatrician present; newborn blood sugar 2 hours after birth

10Randhawa et al. [22]2003PakistanTeaching hospitalRetrospective observational50 women with GDM and diabetes in pregnancyGCT followed by OGTT in weeks 28–32Initial advice on diet and exercise; regular ultrasound for fetal growth, FHR 2x/weekly, biophysical profile weekly in high risk cases after 32 weeksInduction at 38 weeks; CS if >4000 g; in labor FHB and 2-hourly glycaemia; 2nd stage assisted; prophylactic antibiotics. Observed CS rate 50%No specific information provided, but 48% of newborns admitted to neonatal ward

11Ozumba et al. [23]2004NigeriaUniversity hospitalRetrospective observational207 pregnant women diagnosed with diabetesSelective screening;
75 g OGTT; fasting glucose of women with known diabetes
Fortnightly until 32 weeks, weekly thereafter. Follow-up in ANC and by physician in diabetes clinicFasting and postprandial glucose, ultrasound, blood grouping, and rhesus factor, hemoglobin, and urine. No SMBG (only if women can purchase glucometer)Induction at 38 weeks. Vaginal delivery in uncomplicated and well-controlled cases; induced if poorly controlled or complications;
observed CS rate in GDM patients 20%
Women invited for repeat 75 g OGTT 6 weeks postpartum

12Bouhsain et al. [24]2009MoroccoTeaching hospitalRetrospective observational702 pregnant women consulting the gynecology departmentIf RF: screening at first ANC; universal screening at 24–28 weeks; screening with FBG alone or in combination with postprandial glycaemia or 50 g GCT followed by 100 g OGTT in case of GCT positivity

13Dahana-yaka et al. [25]2011Sri LankaDistrict facilitiesCross-sectional descriptive223 pregnant women attending antenatal clinicsSelective screening at >24 weeks: 30.2% women with RF screened. 98% use urine dipstick, 27% postprandial glycaemia, 11% FBG or RBG, and 3% 75 g OGTT

14Divakar & Manyonda [26]2011IndiaNACross-sectional survey584 specialists
OBGY
Universal screening by 82% respondents; 65.5% test at first visit, 97.6% in weeks 24–28; as test 50g GCT done by 39.3%; 75 g OGTT by 26.2%; 14.3% test FBG.

15Divakar & Manyonda [27]2012IndiaNACross-sectional survey584 specialists
OBGY
Fortnightly glucose; 47.6% respondents advise daily home monitoring combined with follow-up visits 2x/month69.1% of clinicians refer women with GDM to specialists64.3% of obstetricians deliver women with GDM ≤ 38 weeks; 35.7% await spontaneous labor but 54.8% wait no longer than 39 weeks57.1% of clinicians refer 10% and 33.3% refer 50% of newborns of mothers with GDM to NICU93% of doctors advise testing 6 weeks postpartum: 56% advise
random glucose tests

16Maiti et al. [28]2012IndiaUrban hospitalProspective observational50 women with GDM75 g OGTTWomen or relatives present results of fortnightly glucose test at clinic every 2 weeksNutritional advice;
3-point profile fortnightly at laboratories close to patient’s home
(no SMBG)
Observed CS rate (GDM): 84%; 82% delivered at term

17Hirst et al. [29]2012VietnamReferral hospitalQualitative study on perceptions & experiences of pregnant women with GDM management4 FGD with 34 women having gestational diabetesUniversal screening;
75 g OGTT in week 28
Admission of noncontrollable casesGlucose monitoring up to 6x dailyWeekly follow-up; glucose checks once or twice weekly at OPD if no SMBGWomen with GDM referred to high risk antenatal clinic: physician provides advice on nutrition. Glucose-surveillance recommended by SMBG or
1-2x/week at OPD

18Nielsen et al. [30]2012Cameroon, China, Cuba,
India, Kenya, and Sudan
Retrospective descriptive; review of screening practices of 9 GDM projects and qualitative assessment of barriersUniversal screening in 78% of 9 GDM projects by random glucose testing (Sudan), fasting glucose followed by OGTT (Cuba, Cameroon, and China); GCT followed by OGTT (Karnataka, India); or OGTT alone (Kenya & 2 states of India)

19Rajagopalan et al. [31]2013IndiaPrivate hospitalRetrospective observationalScreening practices of 753 women booked in ANC; 105 with GDMUniversal screening; 2010–2012: single step at 24 weeks; 2013: screening in each trimester at booking, 26 and 34 weeksAfter diagnosis advise on diet, exercise (and medication)Induction of labor between 38 and 39 weeks; observed CS rate 38%

20Thomas et al. [32]2013IndiaUniversity hospitalProspective observational281 women with GDM requiring medicationGlycaemia
3–7 days after diet initiation
Observed CS rate: 43%; mean gestational age at delivery 37.5 weeksReferral to nursing care: hourly feeding first 6 hours, then 2-hourly; glucose test after 1, 3, 5, 9, and 12 hours; if hypoglycemia iv dextrose

21Gupta et al. [33]2014IndiaNACross-sectional survey134 health care providers (56 OBGY, 78 physicians)59.7% of providers screen selectively based on RF and 30% screen universally; 88.8% respondents screen at first ANC visit: 77.6% of professionals by FBG, 18.6% by RBG, and 3.8% use 75 g OGTT62.7% providers advise glucose test once every 2 weeks, 28.4% weekly

22John et al. [34]2015NigeriaUniversity hospitalRetrospective observational122 pregnant women with diabetes and 101 with GDMSelective screening at booking with 75 g OGTT; repeated at 28 weeksMode of delivery assessed on individual basis depending on glycemic control; observed CS rate 89%49% of newborns admitted to NICU

23Babu et al. [35]2015India70 public health facilitiesCross-sectional survey50 doctorsUniversal screening by 82% doctors: 52% in weeks 16–24. Screening by RBG done by 46% of respondents; GDM diagnosis with 75 g OGTT by 96% respondents54% doctors test sugar postpartum and 36% use FBG; 80% counsel on diet; 82% on exercise; 96% advise follow-up of glycaemia