An Immunomodulatory Device Improves Insulin Resistance in Obese Porcine Model of Metabolic Syndrome

Table 1

Biologic, hematologic, and serum biochemical data collected from Ossabaw swine to determine metabolic status. Animals exhibited at least three of the four cardinal features of MetS (central obesity, dyslipidemia, and hypertension) after 4 months on the high fat diet. Insulin resistance cannot be determined from this data due to the fact that values are averaged over each quarter and overlap periods in which pigs were treated with the SCD. Serial glucose tolerance testing (data not shown) indicated a trend toward insulin resistance in both animals.

Biochemical and physical data of Ossabaw swine
		MET03				MET04
Age (months)		6	10	14	18	6	10	14	18
Months on METS diet		4	8	12	16	4	8	12	16
Parameter	Mean normal value
Weight (kg)	60	43.9	62.7	81.0	90.7	39.8	61.3	78.3	87.3
Abdominal circumference (cm)		96.3	112.0	125.0	168.0	82.0	108.5	122.7	150.0
Blood pressure (mmHg)	88/59	150/94				122/70
Cholesterol (mg/dL)	73.3	420.0	404.0	499.0	341.3	393.3	379.0	277.0	373.0
Fasting triglycerides (mg/dL)	27.0	43.7	26.5	53.0	38.7	27.7	26.0	25.0	24.3
Fasting glucose (mg/dL)	93.0	137.0	90.5	103.0	92.5	95.7	92.5	113.0	93.3
Fasting insulin (uU/mL)		3.2	1.7	2.2	3.0	1.2	1.0	3.5	1.4
HOMA-IR (glu × ins/405)		1.1	0.4	0.6	0.8	0.3	0.2	0.8	0.3

Normal values reported for male Ossabaw swine 12–15 months of age from swine in the laboratory 2nd ed.
Normal range has not been determined for fasting insulin using this assay system.
Since HOMA-IR is a calculation using insulin, a normal range cannot be provided.