Influence of Acute High Glucose on Protein Abundance Changes in Murine Glomerular Mesangial Cells

Figure 2

Network analysis of protein expression patterns using Ingenuity Pathways Analysis. (a) The top scoring network (Network 1) addressed cancer, reproductive system disease, and hematological disease and included 25 identified proteins out of 35 total network components. The score 49 suggests the odds of 1 out of 10⁴⁹ for assembling randomly these protein identifications out of the existing murine protein database. (b) Network 2, defined by IPA, includes PHB. For (a) and (b), red indicates protein spots whose spot volume increased with 2 h high glucose. Green indicates proteins spots whose spot volume decreased with 2 h high glucose.

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