The Expanded Bead Size of Corneal C-Nerve Fibers Visualized by Corneal Confocal Microscopy Is Associated with Slow Conduction Velocity of the Peripheral Nerves in Patients with Type 2 Diabetes Mellitus
Table 4
Relationship between the various measures of corneal nerve fibers and clinical and neurophysiological parameters in patients with type 2 diabetes.
CNFD
CNFL
CNBD
TG
BF
Bead size
β
β
β
β
β
β
Gender
−0.056
0.482
−0.054
0.498
0.093
0.240
−0.040
0.617
−0.083
0.295
0.034
0.669
Age
−0.012
0.882
−0.060
0.450
−0.066
0.405
0.004
0.959
−0.026
0.744
0.057
0.475
Duration of DM
−0.094
0.236
−0.083
0.291
−0.071
0.372
0.036
0.645
−0.025
0.750
−0.040
0.617
SBP
−0.107
0.176
−0.105
0.183
0.011
0.886
−0.107
0.174
−0.010
0.902
−0.032
0.685
DBP
−0.132
0.093
−0.113
0.150
0.015
0.848
−0.139
0.079
−0.004
0.961
0.017
0.830
HbA1c
−0.200
0.011
−0.213
0.007
−0.168
0.032
0.003
0.973
−0.080
0.313
0.352
<0.0001
LDL-C
0.028
0.724
0.011
0.891
−0.007
0.925
0.075
0.343
−0.116
0.141
−0.006
0.937
HDL-C
−0.052
0.509
−0.105
0.182
−0.066
0.403
0.032
0.683
0.027
0.731
−0.043
0.586
Triglycerides
−0.038
0.633
−0.060
0.451
−0.077
0.330
0.034
0.670
−0.015
0.848
0.002
0.984
NDS
−0.255
0.001
−0.208
0.008
−0.019
0.815
0.034
0.665
−0.012
0.883
0.203
0.010
MCV of MN
0.199
0.011
0.193
0.014
0.054
0.494
0.063
0.426
0.050
0.526
−0.358
<0.0001
Amplitude of MN
0.208
0.008
0.172
0.028
−0.009
0.914
−0.083
0.292
−0.028
0.722
0.091
0.248
Distal latency of MN
−0.090
0.256
−0.090
0.256
−0.018
0.819
−0.083
0.295
0.065
0.413
0.294
<0.0001
SCV of UN
0.200
0.011
0.225
0.004
0.138
0.079
0.070
0.379
0.037
0.644
−0.273
<0.0001
Amplitude of UN
0.195
0.013
0.215
0.006
0.040
0.616
−0.031
0.699
0.053
0.504
0.083
0.294
SCV of SN
0.201
0.010
0.223
0.004
0.107
0.175
0.105
0.183
0.031
0.698
−0.237
0.002
Amplitude of SN
0.224
0.004
0.232
0.003
0.076
0.339
−0.064
0.417
0.098
0.215
0.004
0.963
Vibration PT
−0.019
0.812
0.029
0.803
0.016
0.837
0.097
0.220
−0.046
0.562
0.199
0.011
0.161
0.040
0.210
0.007
0.170
0.030
−0.026
0.744
0.009
0.909
−0.098
0.216
Warm PT
0.021
0.790
−0.002
0.985
−0.073
0.358
−0.149
0.058
−0.025
0.753
0.051
0.523
Cold PT
−0.142
0.071
−0.157
0.046
−0.015
0.853
−0.030
0.706
−0.028
0.727
0.025
0.754
BF, beading frequency; CNBD, corneal nerve branch density; CNFD, corneal nerve fiber density; CNFL, corneal nerve fiber length; CV, coefficient of variation; DBP, diastolic blood pressure; DM, diabetes mellitus; HDL-C, high density lipoprotein-cholesterol; LDL-C, low density lipoprotein-cholesterol; MCV, motor conduction velocity; MN, median nerve; NDS, Neuropathy Disability Score; PT, perception threshold; SBP, systolic blood pressure; SCV, sensory conduction velocity; SN, sural nerve; TG, tortuosity grade; UN, ulnar nerve.