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Journal of Diabetes Research
Volume 2016, Article ID 3765173, 7 pages
http://dx.doi.org/10.1155/2016/3765173
Research Article

High Glucose-Induced Oxidative Stress Mediates Apoptosis and Extracellular Matrix Metabolic Imbalances Possibly via p38 MAPK Activation in Rat Nucleus Pulposus Cells

1Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedic Surgery, Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, 639 Zhizaoju Road, Shanghai 200011, China
2Department of Orthopedics, Changzheng Hospital, Second Military Medical University, Shanghai, China
3Department of Toxicity Evaluation, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China

Received 16 November 2015; Revised 25 December 2015; Accepted 28 December 2015

Academic Editor: Mark A. Yorek

Copyright © 2016 Xiaofei Cheng et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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