Abnormal Glucose Tolerance Is Associated with a Reduced Myocardial Metabolic Flexibility in Patients with Dilated Cardiomyopathy

Figure 3

Cardiac energy generation expressed on oxygen equivalents from (a) small molecules, blood born, readily oxidizable substrates (calculated summing up glucose, lactate, and β-OH-butyrate net balances and assuming their full oxidation) as compared to energy generated by NEFA oxidation as measured from [9,10³H]-oleate conversion to ³H₂O in 5 N-AGT (gray line), 4 DCM-NGT (dotted black line), and 4 DCM-AGT (continuous black line) in the 3 phases of the study protocol: Rest, Pacing, and Recovery. The plotted values are mean ± SEM. The thin gray lines represent the SEM of the N-AGT group. indicates a for the comparison between DCM-AGT and DCM-NGT over the study phase by 2-way ANOVA for repeated measures.