Abnormal Glucose Tolerance Is Associated with a Reduced Myocardial Metabolic Flexibility in Patients with Dilated Cardiomyopathy
Table 2
Cardiac net balances of other metabolites.
N-AGT
DCM-NGT
DCM-AGT
Alanine (nmol/min/g)
−17.4 ± 6.3
−7.9 ± 3.4
−7.5 ± 7.6
ns
−16.8 ± 6.8
−14.1 ± 4.2
−8.8 ± 5.2
−18.2 ± 8.1
−5.1 ± 6.7
−8.0 ± 3.1
Pyruvate (nmol/min/g)
12.9 ± 5.8
3.9 ± 2.4
24.8 ± 6.1
<0.05
14.1 ± 5.0
3.8 ± 1.9
32.4 ± 8.1
14.6 ± 4.7
−1.9 ± 2.8
22.6 ± 3.8
Glycerol (nmol/min/g)
−0.3 ± 3.4
2.8 ± 2.5
1.6 ± 2.9
ns
−0.1 ± 3.9
−4.6 ± 5.1
−5.5 ± 8.9
−2.1 ± 2.6
−1.6 ± 3.9
−2.0 ± 1.9
Triglycerides (nmol/min/g)
1.7 ± 5.4
6.0 ± 2.8
3.7 ± 7.1
ns
7.6 ± 4.1
3.5 ± 5.6
−4.6 ± 5.1
7.1 ± 7.4
7.0 ± 4.3
4.2 ± 3.2
Metabolite concentrations were available for all patients: 5 N-AGT, 5 DCM-NGT, and 5 DCM-AGT. values refer to the comparison between N-AGT and DCM-AGT as estimated by 2-way ANOVA for one repeated measure over time.
