Abnormal Glucose Tolerance Is Associated with a Reduced Myocardial Metabolic Flexibility in Patients with Dilated Cardiomyopathy
Table 3
Gas analysis data.
Phase
N-AGT
DCM-AGT
MVO2 (μmol/min/g)
5.7 ± 0.6
4.1 ± 0.6
ns
6.5 ± 0.6
5.1 ± 0.4
5.1 ± 0.4
3.4 ± 0.2
RQ
0.80 ± 0.05
0.80 ± 0.10
<0.05
0.82 ± 0.03
0.77 ± 0.05
0.85 ± 0.04
0.88 ± 0.10
Carbohydrates oxidation (nmol/min/g)
402 ± 83
230 ± 145
<0.02
767 ± 58
208 ± 67
450 ± 102
362 ± 103
Lipids oxidation (nmol/min/g)
160 ± 73
83 ± 32
<0.02
179 ± 44
159 ± 35
101 ± 20
62 ± 33
EE from carbohydrates (cal/min/g)
0.26 ± 0.13
0.15 ± 0.08
<0.02
0.51 ± 0.04
0.14 ± 0.06
0.30 ± 0.09
0.24 ± 0.09
EE from lipids (cal/min/g)
0.38 ± 0.09
0.20 ± 0.10
<0.02
0.43 ± 0.11
0.38 ± 0.08
0.33 ± 0.09
0.21 ± 0.08
Gas analysis data were available for a subset of patients: 4 DCM-NGT and 4 DCM-AGT. values refer to the comparison between N-AGT and DCM-AGT as estimated by 2-way ANOVA for one repeated measure over time. for the comparison with the preceding study protocol step ( versus and versus ). MVO2: myocardial oxygen uptake; RQ: respiratory quotient; EE: energy expenditure.
