Reversal of Early Diabetic Nephropathy by Islet Transplantation under the Kidney Capsule in a Rat Model

Figure 5

Measurement of IOD/area of immunohistochemical staining of renal fibrogenic and interstitial fibrosis factors. (a) Measurement of IOD/area of TGF-β1, , and . (b) Measurement of IOD/area of CTGF, and . (c) Measurement of IOD/area of HGF, and . (d) Measurement of IOD/area of MCP-1, and . (e) Measurement of IOD/area of α-SMA, and . IOD/area, integrated optical density/area. The mean of IOD/area of positive staining was used to accurately measure the degree of positive expression in immunohistochemical staining. Model group: diabetic nephropathy model rats established at 12 weeks.

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