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Journal of Diabetes Research
Volume 2016, Article ID 4365156, 6 pages
Research Article

Coronary Plaque Characteristics Assessed by 256-Slice Coronary CT Angiography and Association with High-Sensitivity C-Reactive Protein in Symptomatic Patients with Type 2 Diabetes

1Department of CT, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China
2Department of Radiology, Xuanwu Hospital, Beijing 100053, China
3Biomedical Imaging Research Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA

Received 1 March 2016; Accepted 24 March 2016

Academic Editor: Konstantinos Papatheodorou

Copyright © 2016 Jinling Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Little is known regarding plaque distribution, composition, and the association with inflammation in type 2 diabetes mellitus (DM2). This study aimed to assess the relationship between coronary plaque subtypes and high-sensitivity C-reactive protein levels. Coronary CTA were performed in 98 symptomatic DM2 patients and 107 non-DM2 patients using a 256-slice CT. The extent and types of plaque as well as luminal narrowing were evaluated. Patients with DM2 were more likely to have significant stenosis (>50%) with calcified plaques in at least one coronary segment (); the prevalence rates of diffuse calcified plaques in the DM2 and non-DM2 groups were 31.6% and 4.7%, respectively (). Plasma hs-CRP levels in DM2 with calcified plaques were higher compared with values obtained for the non-DM2 group (). In conclusion, combination of coronary CTA and hs-CRP might improve risk stratification in symptomatic DM2 patients.