Studies on the Antidiabetic and Antinephritic Activities of Paecilomyces hepiali Water Extract in Diet-Streptozotocin-Induced Diabetic Sprague Dawley Rats
Table 2
The regulatory effects of Met and PHC on the inflammatory related factors in diabetic rats.
Control
Model
0.12 g/kg Met
0.08 g/kg PHC
0.4 g/kg PHC
2.0 g/kg PHC
Serum
IL-2 (pg/mL)
67.77 ± 3.08
89.10 ± 6.06#
83.93 ± 14.03
76.1 ± 3.27
72.77 ± 5.91
72.1 ± 1.71
IL-6 (pg/mL)
6.51 ± 0.24
7.28 ± 0.23#
5.04 ± 0.31
5.59 ± 0.36
5.54 ± 0.32
5.29 ± 0.32
IL-10 (pg/mL)
3.32 ± 0.19
5.20 ± 0.47##
3.75 ± 0.27
3.94 ± 0.16
4.39 ± 0.21
3.56 ± 0.14
TNF-α (pg/mL)
9.88 ± 0.55
12.15 ± 0.37##
11.12 ± 0.72
11.15 ± 1.04
9.75 ± 0.65
8.96 ± 0.68
Kidney
IL-2 (pg/g)
3394 ± 735
6932 ± 344##
4065 ± 1060
2804 ± 437
3189 ± 265
3101 ± 754
IL-6 (pg/g)
10.86 ± 1.29
72.73 ± 17.88##
30.17 ± 7.31
46.18 ± 5.44
47.49 ± 7.35
17.53 ± 2.78
IL-10 (pg/g)
27.78 ± 2.66
40.66 ± 5.33#
28.41 ± 3.60
27.65 ± 2.05
28.91 ± 3.14
23.90 ± 2.25
TNF-α (pg/g)
283.96 ± 38.16
416.3 ± 28.7#
328.30 ± 76.23
223.21 ± 29.68
225.66 ± 26.57
158.49 ± 41.27
The levels of IL-2, IL-6, IL-10, and TNF-α in serum and kidney were determined and detected after 4-week administration of Met (0.12 g/kg) or PHC (0.08, 0.4, and 2.0 g/kg). Data are expressed as mean ± SD () and analyzed by one-way ANOVA. and versus normal controls, and versus model group.
