Studies on the Antidiabetic and Antinephritic Activities of Paecilomyces hepiali Water Extract in Diet-Streptozotocin-Induced Diabetic Sprague Dawley Rats

Table 3

The regulatory effects of Met and PHC on the oxidative damage related factors in diabetic rats.

		Control	Model	0.12 g/kg Met	0.08 g/kg PHC	0.4 g/kg PHC	2.0 g/kg PHC
Serum	MDA (nmol/mL)	11.78 ± 2.49	17.63 ± 2.21	5.87 ± 1.19	15.11 ± 1.17	14.56 ± 3.71	12.73 ± 2.45
	SOD (U/mL)	55.72 ± 2.49	50.77 ± 1.89	60.04 ± 1.64	55.63 ± 1.58	55.48 ± 1.92	55.94 ± 1.46
	GSH-Px (μmol/L)	243.28 ± 30.62	119.40 ± 11.77^##	218.66 ± 34.98	111.94 ± 11.33	134.33 ± 16.43	148.51 ± 33.30
Kidney	MDA (nmol/mgprot)	5.05 ± 0.43	7.08 ± 0.67^#	3.94 ± 0.30	6.88 ± 0.27	6.77 ± 0.51	4.71 ± 0.30
	SOD (U/mgprot)	121.94 ± 9.03	60.15 ± 13.79^##	75.97 ± 15.06	112.19 ± 15.06	99.21 ± 12.82	111.51 ± 10.66
	GSH-Px (µmol/gprot)	6328.2 ± 518.0	3439.5 ± 776.5^#	5910.2 ± 888.8	6806.6 ± 970.3	7348.9 ± 2108.2	7334.7 ± 958.6

After four-week Met and PHC treatment at indicated doses, the levels of MDA, SOD, and GSH-Px in serum and kidney were determined. Data are expressed as mean ± SD () and analyzed by using one-way ANOVA. and versus normal controls, and versus model group.