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Journal of Diabetes Research
Volume 2016, Article ID 4370490, 7 pages
Research Article

Xanthine Oxidase Activity in Type 2 Diabetes Mellitus Patients with and without Diabetic Peripheral Neuropathy

1Institute of Biochemistry, Medical Faculty, University of Pristina, Kosovska Mitrovica, Serbia
2Clinics for Neurology and Psychiatry, Medical Faculty, University of Pristina, Kosovska Mitrovica, Serbia
3Clinics for General and Orthopedics Surgery, Medical Faculty, University of Pristina, Kosovska Mitrovica, Serbia
4Biochemical Laboratory, Medical Faculty, University of East Sarajevo, Foca, Bosnia And Herzegovina

Received 8 September 2016; Revised 22 October 2016; Accepted 26 October 2016

Academic Editor: Norman Cameron

Copyright © 2016 Dijana J. Miric et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


This study investigated the relationship between serum xanthine oxidase (XOD) activity and the occurrence of diabetic peripheral neuropathy (DPN) in type 2 diabetes mellitus (T2DM) patients. Serum XOD activity, ischemia-modified albumin (IMA), uric acid (UA), albumin, glycated hemoglobin (HbA1c), advanced glycation end products (AGE), total free thiols, atherogenic index of plasma (AIP), and body mass index (BMI) were measured in 80 T2DM patients (29 with and 51 without DPN), and 30 nondiabetic control subjects. Duration of diabetes, hypertension, medication, and microalbuminuria was recorded. Serum XOD activities in controls, non-DPN, and DPN were  U/L,  U/L, and  U/L (), respectively. XOD activity was directly correlated to IMA, UA, BMI, HbA1c, and AGE, while inversely correlated to serum total free thiols. A multivariable logistic regression model, which included duration of diabetes, hypertension, AIP, HbA1c, UA, and XOD activity, revealed HbA1c [OR = 1.03 (1.00–1.05); ] and XOD activity [OR = 1.07 (1.00–1.14); ] as independent predictors of DPN. Serum XOD activity was well correlated to several other risk factors. These results indicate the role of XOD in the development of DPN among T2DM patients.