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Journal of Diabetes Research
Volume 2016, Article ID 4396756, 8 pages
Research Article

Collagen V Is a Potential Substrate for Clostridial Collagenase G in Pancreatic Islet Isolation

1Department of Biochemistry, Tohoku University Graduate School of Medicine, Sendai 980-8575, Japan
2AMED-CREST, Japan Agency for Medical Research and Development, Tokyo 100-0004, Japan
3Division of Transplantation and Regenerative Medicine, Tohoku University School of Medicine, Sendai 980-8575, Japan
4New Industry Creation Hatchery Center, Tohoku University, Sendai 980-8579, Japan
5Graduate School of Agricultural Science, Tokyo University of Agriculture and Technology, Fuchu 183-8509, Japan
6Center for Regulatory Epigenome and Diseases, Tohoku University Graduate School of Medicine, Sendai 980-8575, Japan
7Graduate School of Biomedical Engineering, Tohoku University, Sendai 980-8575, Japan

Received 19 February 2016; Accepted 27 March 2016

Academic Editor: Pedro M. Geraldes

Copyright © 2016 Hiroki Shima et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Supplementary figure 1: Sequences of collagen a1, a2, and a3. The Gly-Xaa-Yaa repeats are denoted in individual block. The red and blue triangles indicate the cleavage sites detected for the sample which is digested 60 min and 3 min, respectively. The hydroxylproline positions in a1(V) are shown in green.

  1. Supplementary Material