Gmelina arborea Roxb. (Family: Verbenaceae) Extract Upregulates the β-Cell Regeneration in STZ Induced Diabetic Rats

Figure 4

(a–d) Photomicrographs of insulin immune reactivity in pancreatic islets with anti-insulin antibody (×400). (a) Healthy control rats, a normal islet composed predominantly of insulin secreting cells. (b) Diabetic control rats, marked reduction in the number of insulin secreting β-cells due to the destruction of islet cells by streptozotocin. (c) Gmelina arborea (1.00 g/kg) treated (1.00 g/kg) rats, an islet with a marked increase in insulin secreting β-cells. (d) Glibenclamide treated (0.50 mg/kg) rats, mild increase in insulin secreting β-cells.

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