Research Article
Modeling and Measurement of Correlation between Blood and Interstitial Glucose Changes
Figure 3
Measurements of blood and ISF glucose changes with 3H-labeled glucose in rat. (a) Time course of 3H-labeled glucose activity measured in blood and ISF of rats. (b) Time course of glucose concentration changes in blood and ISF of rats. (c) Comparisons of glucose changes measured in blood (BG) and interstitial fluid (ISFG) of rats with the time courses generated by the theoretical simulations. is the blood flow and is the glucose extraction from blood related to glucose membrane permeability ensued in the theoretical model. The changes of 3H isotope levels in blood and tissue can reflect the changes of glucose levels in these two compartments after isotope activity was converted with the equation of = . and are 3H isotope activities in blood and ISF, respectively. and represent blood glucose and ISF glucose concentrations, respectively. For the in vivo studies, 5 experimental rats with similar size and weight were used.
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