Research Article

Calpain-Calcineurin-Nuclear Factor Signaling and the Development of Atrial Fibrillation in Patients with Valvular Heart Disease and Diabetes

Table 2

Clinical assessments of patients.

AF ()SR ()

Age (years)51.20 ± 6.3350.06 ± 9.260.524
Sex (male, %)24 (53.33%)18 (56.25%)0.800
Cigarette smoking9 (20.00%)7 (21.88%)0.842
Alcohol drinking13 (28.89%)11 (34.38%)0.609
Diseases
 MS14 (31.11%)10 (31.25%)0.505
 MR22 (48.89%)18 (56.25%)
 MS + MR6 (13.33%)4 (12.50%)
 MS + MR + AS/AR3 (6.67%)0
Physical examination
 Systolic BP (mmHg)120.22 ± 8.40123.31 ± 12.620.201
 Diastolic BP (mmHg)75.98 ± 8.0173.06 ± 10.540.172
 Rest heart rates (bpm)81.13 ± 14.7474.03 ± 8.910.011
Cardiac function
 NYHA class II11 (24.44%)17 (53.13%)0.019
 NYHA class III34 (75.56%)15 (46.87%)
Medications
 ACEI (%)8 (19.03%)3 (9.38%)0.345
-blockers (%)18 (40.00%)4 (12.50%)0.011
 Digoxin (%)25 (55.56%)0 <0.001
 Diuretics (%)45 (100%)18 (58.25%)<0.001

ACEI, angiotensin-converting enzyme inhibitors; AF, atrial fibrillation; AR, aortic regurgitation; AS, aortic stenosis; BP, blood pressure; bpm, beats per minute; MR, mitral regurgitation; MS, mitral stenosis; NYHA, New York Heart Association; SR, sinus rhythm.