Table of Contents Author Guidelines Submit a Manuscript
Journal of Diabetes Research
Volume 2016, Article ID 4692478, 17 pages
http://dx.doi.org/10.1155/2016/4692478
Research Article

Par-4/NF-κB Mediates the Apoptosis of Islet β Cells Induced by Glucolipotoxicity

1Endocrine Department, The First Affiliated Hospital of the Third Military Medical University, Chong Qing 400038, China
2Outpatient Department, The First Affiliated Hospital of the Third Military Medical University, Chong Qing 400038, China

Received 27 February 2016; Accepted 4 April 2016

Academic Editor: Xin Ma

Copyright © 2016 Wu QiNan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. A. E. Butler and S. Dhawan, “β-Cell identity in type 2 diabetes: lost or found?” Diabetes, vol. 64, no. 8, pp. 2698–2700, 2015. View at Publisher · View at Google Scholar · View at Scopus
  2. M. Cnop, B. Abdulkarim, G. Bottu et al., “RNA sequencing identifies dysregulation of the human pancreatic islet transcriptome by the saturated fatty acid palmitate,” Diabetes, vol. 63, no. 6, pp. 1978–1993, 2014. View at Publisher · View at Google Scholar · View at Scopus
  3. J.-H. Lee, I.-R. Jung, S.-E. Choi et al., “Toxicity generated through inhibition of pyruvate carboxylase and carnitine palmitoyl transferase-1 is similar to high glucose/palmitate-induced glucolipotoxicity in INS-1 β cells,” Molecular and Cellular Endocrinology, vol. 383, no. 1-2, pp. 48–59, 2014. View at Publisher · View at Google Scholar · View at Scopus
  4. M. Bensellam, D. R. Laybutt, and J.-C. Jonas, “The molecular mechanisms of pancreatic β-cell glucotoxicity: recent findings and future research directions,” Molecular and Cellular Endocrinology, vol. 364, no. 1-2, pp. 1–27, 2012. View at Publisher · View at Google Scholar · View at Scopus
  5. K. Nyalakonda, T. Sharma, and F. Ismail-Beigi, “Preservation of β-cell function in type 2 diabetes,” Endocrine Practice, vol. 16, no. 6, pp. 1038–1055, 2010. View at Publisher · View at Google Scholar · View at Scopus
  6. E. S. O'Sullivan, A. Vegas, D. G. Anderson, and G. C. Weir, “Islets transplanted in immunoisolation devices: a review of the progress and the challenges that remain,” Endocrine Reviews, vol. 32, no. 6, pp. 827–844, 2011. View at Publisher · View at Google Scholar · View at Scopus
  7. P. Walter and D. Ron, “The unfolded protein response: from stress pathway to homeostatic regulation,” Science, vol. 334, no. 6059, pp. 1081–1086, 2011. View at Publisher · View at Google Scholar · View at Scopus
  8. S. Gurumurthy, A. Goswami, K. M. Vasudevan, and V. M. Rangnekar, “Phosphorylation of par-4 by protein kinase A is critical for apoptosis,” Molecular and Cellular Biology, vol. 25, no. 3, pp. 1146–1161, 2005. View at Publisher · View at Google Scholar · View at Scopus
  9. I. García-Cao, A. Duran, M. Collado et al., “Tumour-suppression activity of the proapoptotic regulator Par4,” EMBO Reports, vol. 6, no. 6, pp. 577–583, 2005. View at Publisher · View at Google Scholar · View at Scopus
  10. F. Thayyullathil, S. Pallichankandy, A. Rahman et al., “Caspase-3 mediated release of SAC domain containing fragment from par-4 is necessary for the sphingosine-induced apoptosis in Jurkat cells,” Journal of Molecular Signaling, vol. 8, article 2, 2013. View at Publisher · View at Google Scholar · View at Scopus
  11. R. Burikhanov, T. Shrestha-Bhattarai, S. Qiu et al., “Novel mechanism of apoptosis resistance in cancer mediated by extracellular PAR-4,” Cancer Research, vol. 73, no. 2, pp. 1011–1019, 2013. View at Publisher · View at Google Scholar · View at Scopus
  12. R. Burikhanov, Y. Zhao, A. Goswami, S. Qiu, S. R. Schwarze, and V. M. Rangnekar, “The tumor suppressor Par-4 activates an extrinsic pathway for apoptosis,” Cell, vol. 138, no. 2, pp. 377–388, 2009. View at Publisher · View at Google Scholar · View at Scopus
  13. W. Qinan, Z. Ling, and C. Bing, “PAR-4: a possible new target for age-related disease,” Expert Opinion on Therapeutic Targets, vol. 18, no. 8, pp. 917–927, 2014. View at Publisher · View at Google Scholar · View at Scopus
  14. J. Y. Chan, T. J. Biden, and D. R. Laybutt, “Cross-talk between the unfolded protein response and nuclear factor-κB signalling pathways regulates cytokine-mediated β cell death in MIN6 cells and isolated mouse islets,” Diabetologia, vol. 55, pp. 2999–3009, 2012. View at Google Scholar
  15. Y. Xu, L. Wang, J. He et al., “Prevalence and control of diabetes in Chinese adults,” The Journal of the American Medical Association, vol. 310, no. 9, pp. 948–959, 2013. View at Publisher · View at Google Scholar · View at Scopus
  16. A. E. Butler, J. Janson, S. Bonner-Weir, R. Ritzel, R. A. Rizza, and P. C. Butler, “β-Cell deficit and increased β-cell apoptosis in humans with type 2 diabetes,” Diabetes, vol. 52, no. 1, pp. 102–110, 2003. View at Publisher · View at Google Scholar · View at Scopus
  17. G. Leibowitz, N. Kaiser, and E. Cerasi, “Balancing needs and means: the dilemma of the β-cell in the modern world,” Diabetes, Obesity and Metabolism, vol. 11, supplement 4, pp. 1–9, 2009. View at Publisher · View at Google Scholar · View at Scopus
  18. U. Özcan, Q. Cao, E. Yilmaz et al., “Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes,” Science, vol. 306, no. 5695, pp. 457–461, 2004. View at Publisher · View at Google Scholar · View at Scopus
  19. J. Shirakawa, Y. Togashi, E. Sakamoto et al., “Glucokinase activation ameliorates ER stress-induced apoptosis in pancreatic β-cells,” Diabetes, vol. 62, no. 10, pp. 3448–3458, 2013. View at Publisher · View at Google Scholar · View at Scopus
  20. E. Araki, S. Oyadomari, and M. Mori, “Impact of endoplasmic reticulum stress pathway on pancreatic β-cells and diabetes mellitus,” Experimental Biology and Medicine, vol. 228, no. 10, pp. 1213–1217, 2003. View at Google Scholar · View at Scopus
  21. S. Oyadomari, A. Koizumi, K. Takeda et al., “Targeted disruption of the chop gene delays endoplasmic reticulum stress-mediated diabetes,” The Journal of Clinical Investigation, vol. 109, no. 4, pp. 525–532, 2002. View at Publisher · View at Google Scholar · View at Scopus
  22. T. Shrestha-Bhattarai and V. M. Rangnekar, “Cancer-selective apoptotic effects of extracellular and intracellular Par-4,” Oncogene, vol. 29, no. 27, pp. 3873–3880, 2010. View at Publisher · View at Google Scholar · View at Scopus
  23. J. V. Alvarez, T.-C. Pan, J. Ruth et al., “Par-4 downregulation promotes breast cancer recurrence by preventing multinucleation following targeted therapy,” Cancer Cell, vol. 24, no. 1, pp. 30–44, 2013. View at Publisher · View at Google Scholar · View at Scopus
  24. C. L. B. Kline and R. B. Irby, “The pro-apoptotic protein prostate apoptosis response protein-4 (Par-4) can be activated in colon cancer cells by treatment with Src inhibitor and 5-FU,” Apoptosis, vol. 16, no. 12, pp. 1285–1294, 2011. View at Publisher · View at Google Scholar · View at Scopus
  25. W. Qi Nan, Z. Ling, and C. Bing, “The influence of the telomere-telomerase system on diabetes mellitus and its vascular complications,” Expert Opinion on Therapeutic Targets, vol. 19, no. 6, pp. 849–864, 2015. View at Publisher · View at Google Scholar · View at Scopus
  26. J. Staal, T. Bekaert, and R. Beyaert, “Regulation of NF-κB signaling by caspases and MALT1 paracaspase,” Cell Research, vol. 21, no. 1, pp. 40–54, 2011. View at Publisher · View at Google Scholar · View at Scopus
  27. D. Jia, L.-J. Heng, R.-H. Yang, and G.-D. Gao, “Fish oil improves learning impairments of diabetic rats by blocking PI3K/AKT/nuclear factor-κB-mediated inflammatory pathways,” Neuroscience, vol. 258, pp. 228–237, 2014. View at Publisher · View at Google Scholar · View at Scopus
  28. C. Putinski, M. Abdul-Ghani, R. Stiles et al., “Intrinsic-mediated caspase activation is essential for cardiomyocyte hypertrophy,” Proceedings of the National Academy of Sciences of the United States of America, vol. 110, no. 43, pp. E4079–E4087, 2013. View at Publisher · View at Google Scholar · View at Scopus
  29. W. Q. Nan, T. Q. Shan, X. Qian, W. Ping, G. A. Bing, and L. L. Ying, “PPARα agonist prevented the apoptosis induced by glucose and fatty acid in neonatal cardiomyocytes,” Journal of Endocrinological Investigation, vol. 34, no. 4, pp. 271–275, 2011. View at Publisher · View at Google Scholar · View at Scopus