Table of Contents Author Guidelines Submit a Manuscript
Journal of Diabetes Research
Volume 2016, Article ID 4840203, 10 pages
http://dx.doi.org/10.1155/2016/4840203
Research Article

Comparison of Experimental Diabetic Periodontitis Induced by Porphyromonas gingivalis in Mice

1State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, No. 14, 3rd Section S. Renmin Road, Chengdu, China
2Center for Dental Research, School of Dentistry, Loma Linda University, 11175 Campus Street, Loma Linda, CA, USA
3Shandong Provincial Key Laboratory of Oral Tissue Regeneration, School of Stomatology, Shandong University, 44-1 Wenhua W. Road, Jinan, China
4Department of Prosthodontics, The Affiliated Hospital of Stomatology, Guangxi Medical University, 10 Shuangyong Road, Nanning 530021, China

Received 9 June 2016; Accepted 2 November 2016

Academic Editor: Jose López-López

Copyright © 2016 Qi Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. Pacios, J. Kang, J. Galicia et al., “Diabetes aggravates periodontitis by limiting repair through enhanced inflammation,” The FASEB Journal, vol. 26, no. 4, pp. 1423–1430, 2012. View at Publisher · View at Google Scholar · View at Scopus
  2. M. C. Denis, U. Mahmood, C. Benoist, D. Mathis, and R. Weissleder, “Imaging inflammation of the pancreatic islets in type 1 diabetes,” Proceedings of the National Academy of Sciences of the United States of America, vol. 101, no. 34, pp. 12634–12639, 2004. View at Publisher · View at Google Scholar · View at Scopus
  3. A. Gastaldelli, “Role of beta-cell dysfunction, ectopic fat accumulation and insulin resistance in the pathogenesis of type 2 diabetes mellitus,” Diabetes Research and Clinical Practice, vol. 93, supplement 1, pp. S60–S65, 2011. View at Publisher · View at Google Scholar · View at Scopus
  4. Y.-Y. Wu, E. Xiao, and D. T. Graves, “Diabetes mellitus related bone metabolism and periodontal disease,” International Journal of Oral Science, vol. 7, no. 2, pp. 63–72, 2015. View at Publisher · View at Google Scholar · View at Scopus
  5. P. M. Preshaw, A. L. Alba, D. Herrera et al., “Periodontitis and diabetes: a two-way relationship,” Diabetologia, vol. 55, no. 1, pp. 21–31, 2012. View at Publisher · View at Google Scholar · View at Scopus
  6. V. Ilievski, Y. Cho, P. Katwala et al., “TLR4 expression by liver resident cells mediates the development of glucose intolerance and insulin resistance in experimental periodontitis,” PLoS ONE, vol. 10, no. 8, Article ID e0136502, 2015. View at Publisher · View at Google Scholar · View at Scopus
  7. P. M. Duarte, J. P. Bezerra, T. S. Miranda, M. Feres, L. Chambrone, and L. M. Shaddox, “Local levels of inflammatory mediators in uncontrolled type 2 diabetic subjects with chronic periodontitis,” Journal of Clinical Periodontology, vol. 41, no. 1, pp. 11–18, 2014. View at Publisher · View at Google Scholar · View at Scopus
  8. P. M. Duarte, T. S. Miranda, J. A. Lima et al., “Expression of immune-inflammatory markers in sites of chronic periodontitis in patients with type 2 diabetes,” Journal of Periodontology, vol. 83, no. 4, pp. 426–434, 2012. View at Publisher · View at Google Scholar · View at Scopus
  9. S. Bussières-Marmen, A. P. Hutchins, A. Schirbel et al., “Characterization of PTPN2 and its use as a biomarker,” Methods, vol. 65, no. 2, pp. 239–246, 2014. View at Publisher · View at Google Scholar · View at Scopus
  10. F. Wiede, B. J. Shields, S. H. Chew et al., “T cell protein tyrosine phosphatase attenuates T cell signaling to maintain tolerance in mice,” Journal of Clinical Investigation, vol. 121, no. 12, pp. 4758–4774, 2011. View at Publisher · View at Google Scholar · View at Scopus
  11. M. Scharl, D. F. McCole, A. Weber et al., “Protein tyrosine phosphatase N2 regulates TNFα-induced signalling and cytokine secretion in human intestinal epithelial cells,” Gut, vol. 60, no. 2, pp. 189–197, 2011. View at Publisher · View at Google Scholar · View at Scopus
  12. M. L. Colli, F. Moore, E. N. Gurzov, F. Ortis, and D. L. Eizirik, “MDA5 and PTPN2, two candidate genes for type 1 diabetes, modify pancreatic β-cell responses to the viral by-product double-stranded RNA,” Human Molecular Genetics, vol. 19, no. 1, pp. 135–146, 2010. View at Publisher · View at Google Scholar · View at Scopus
  13. W.-L. Sun, L.-L. Chen, S.-Z. Zhang, Y.-M. Wu, Y.-Z. Ren, and G.-M. Qin, “Infammatory cytokines, adiponectin, insulin resistance and metabolic control after periodontal intervention in patients with type 2 diabetes and chronic periodontitis,” Internal Medicine, vol. 50, no. 15, pp. 1569–1574, 2011. View at Publisher · View at Google Scholar · View at Scopus
  14. A. J. F. King, “The use of animal models in diabetes research,” British Journal of Pharmacology, vol. 166, no. 3, pp. 877–894, 2012. View at Publisher · View at Google Scholar · View at Scopus
  15. X.-F. Hua, Y.-W. Wang, Y.-X. Tang et al., “Pancreatic insulin-producing cells differentiated from human embryonic stem cells correct hyperglycemia in SCID/NOD mice, an animal model of diabetes,” PLoS ONE, vol. 9, no. 7, Article ID e102198, 2014. View at Publisher · View at Google Scholar · View at Scopus
  16. T. Abe and G. Hajishengallis, “Optimization of the ligature-induced periodontitis model in mice,” Journal of Immunological Methods, vol. 394, no. 1-2, pp. 49–54, 2013. View at Publisher · View at Google Scholar · View at Scopus
  17. U. K. Bhawal, H. J. Lee, K. Arikawa et al., “Micromolar sodium fluoride mediates anti-osteoclastogenesis in Porphyromonas gingivalis-induced alveolar bone loss,” International Journal of Oral Science, vol. 7, no. 4, pp. 242–249, 2015. View at Google Scholar
  18. P. Goes, I. M. Melo, L. M. C. M. Silva et al., “Low-dose combination of alendronate and atorvastatin reduces ligature-induced alveolar bone loss in rats,” Journal of Periodontal Research, vol. 49, no. 1, pp. 45–54, 2014. View at Publisher · View at Google Scholar · View at Scopus
  19. H. Li, H. Xie, M. Fu et al., “25-hydroxyvitamin D3 ameliorates periodontitis by modulating the expression of inflammation-associated factors in diabetic mice,” Steroids, vol. 78, no. 2, pp. 115–120, 2013. View at Publisher · View at Google Scholar · View at Scopus
  20. R. Sulniute, T. Lindh, M. Wilczynska, J. Li, and T. Ny, “Plasmin is essential in preventing periodontitis in mice,” The American Journal of Pathology, vol. 179, no. 2, pp. 819–828, 2011. View at Publisher · View at Google Scholar · View at Scopus
  21. C.-Y. Bang and S.-Y. Choung, “Enzogenol improves diabetes-related metabolic change in C57BL/KsJ-db/db mice, a model of type 2 diabetes mellitus,” The Journal of Pharmacy and Pharmacology, vol. 66, no. 6, pp. 875–885, 2014. View at Publisher · View at Google Scholar · View at Scopus
  22. H. Y. Won, J.-A. Lee, Z. S. Park et al., “Prominent bone loss mediated by RANKL and IL-17 produced by CD4+ T cells in tallyho/JngJ mice,” PLoS ONE, vol. 6, no. 3, Article ID e18168, 2011. View at Publisher · View at Google Scholar · View at Scopus
  23. J. F. López-Acosta, P. Villa-Pérez, C. M. Fernández-Díaz et al., “Protective effects of epoxypukalide on pancreatic beta-cells and glucose metabolism in STZ-induced diabetic mice,” Islets, vol. 7, no. 2, Article ID e1078053, 2015. View at Publisher · View at Google Scholar
  24. H. Duan, B. Ma, X. Ma et al., “Anti-diabetic activity of recombinant irisin in STZ-induced insulin-deficient diabetic mice,” International Journal of Biological Macromolecules, vol. 84, pp. 457–463, 2016. View at Publisher · View at Google Scholar · View at Scopus
  25. Y. Aoki-Nonaka, T. Nakajima, S. Miyauchi et al., “Natural killer T cells mediate alveolar bone resorption and a systemic inflammatory response in response to oral infection of mice with Porphyromonas gingivalis,” Journal of Periodontal Research, vol. 49, no. 1, pp. 69–76, 2014. View at Publisher · View at Google Scholar · View at Scopus
  26. Y. M. Tan, J. Hou, X. J. Yang et al., “Effects of intracellular Porphyromonas gingivalis on proliferation and osteogenic differentiation of human periodontal ligament cells in vitro,” Nan Fang Yi Ke Da Xue Xue Bao, vol. 36, no. 4, pp. 525–531, 2016. View at Google Scholar
  27. X. Han, K. B. LaRosa, T. Kawai, and M. A. Taubman, “DNA-based adaptive immunity protect host from infection-associated periodontal bone resorption via recognition of Porphyromonas gingivalis virulence component,” Vaccine, vol. 32, no. 2, pp. 297–303, 2014. View at Publisher · View at Google Scholar · View at Scopus
  28. P. J. Baker, M. Dixon, R. T. Evans, and D. C. Roopenian, “Heterogeneity of Porphyromonas gingivalis strains in the induction of alveolar bone loss in mice,” Oral Microbiology and Immunology, vol. 15, no. 1, pp. 27–32, 2000. View at Publisher · View at Google Scholar · View at Scopus
  29. E. L. Tenorio, B. A. Klein, W. S. Cheung, and L. T. Hu, “Identification of interspecies interactions affecting Porphyromonas gingivalis virulence phenotypes,” Journal of Oral Microbiology, vol. 3, article 8396, 2011. View at Publisher · View at Google Scholar · View at Scopus
  30. O. Kose, T. Arabaci, A. Kara et al., “Effects of melatonin on oxidative stress index and alveolar bone loss in diabetic rats with periodontitis,” Journal of Periodontology, vol. 87, no. 5, pp. e82–e90, 2016. View at Publisher · View at Google Scholar
  31. J. M. Bruun, C. Verdich, S. Toubro, A. Astrup, and B. Richelsen, “Association between measures of insulin sensitivity and circulating levels of interleukin-8, interleukin-6 and tumor necrosis factor-α. Effect of weight loss in obese men,” European Journal of Endocrinology/European Federation of Endocrine Societies, vol. 148, no. 5, pp. 535–542, 2003. View at Publisher · View at Google Scholar · View at Scopus
  32. C. Sima, K. Rhourida, T. E. Van Dyke, and R. Gyurko, “Type 1 diabetes predisposes to enhanced gingival leukocyte margination and macromolecule extravasation in vivo,” Journal of Periodontal Research, vol. 45, no. 6, pp. 748–756, 2010. View at Publisher · View at Google Scholar · View at Scopus
  33. S.-W. Hassan, K. M. Doody, S. Hardy, N. Uetani, D. Cournoyer, and M. L. Tremblay, “Increased susceptibility to dextran sulfate sodium induced colitis in the T cell protein tyrosine phosphatase heterozygous mouse,” PLoS ONE, vol. 5, no. 1, Article ID e8868, 2010. View at Publisher · View at Google Scholar · View at Scopus