Exogenous Angiotensin I Metabolism in Aorta Isolated from Streptozotocin Treated Diabetic Rats

Table 3

Concentrations of the products of metabolism of exogenously added (to a final concentration of 1 µM) angiotensin I by the aorta fragments pretreated with thiorphan (final concentration 3 µM) from streptozotocin and saline treated animals (pg/mg of dry tissue; median [25th, 75th percentile]). values are from Kruskal-Wallis nonparametric tests.

Analyte	Concentration in streptozotocin treated rats (), pg/mg of dry tissue; median [25th, 75th percentile]	Concentration in control rats (), pg/mg of dry tissue; median [25th, 75th percentile]	value
Angiotensin I	912.83 [725.58, 1036.16]	627.72 [556.23, 659.39]	0.06
Angiotensin II	4.90 [3.63, 5.57]	3.73 [2.93, 4.19]	0.14
Angiotensin III	3.24 [2.47, 4.79]	2.63 [2.36, 3.38]	0.34
Angiotensin IV	1.04 [0.93, 1.44]	0.91 [0.68, 1.15]	0.14
Angiotensin (1–9)	2.81 [1.79, 4.67]	3.05 [1.76, 4.47]	0.95
Angiotensin (1–7)	2.51 [1.99, 3.17]	2.53 [1.85, 3.06]	0.95
Angiotensin (1–5)	1.41 [0.86, 1.55]	0.97 [0.65, 1.22]	0.14