Exogenous Angiotensin I Metabolism in Aorta Isolated from Streptozotocin Treated Diabetic Rats

Table 4

Ratios of concentrations of the products of classical and alternative pathways of exogenous ANG I (1 µM) metabolism by aorta fragments of streptozotocin and saline treated animals (median [25th, 75th percentile]). values are from Kruskal-Wallis nonparametric tests.

Ratio	Streptozotocin treated rats (); median [25th, 75th percentile]	Control rats (); median [25th, 75th percentile]	value
No pretreatment
ANG II/ANG (1–9)	3.98 [2.64, 4.96]	2.03 [1.50, 8.37]	0.22
ANG II/ANG (1–7)	4.90 [3.96, 7.33]	4.16 [1.93, 5.02]	0.13
ANG III/ANG (1–9)	1.20 [1.02, 1.67]	0.83 [0.53, 2.34]	0.22
ANG III/ANG (1–7)	1.63 [1.42, 1.94]	1.29 [1.15, 1.47]	0.03
ANG IV/ANG (1–9)	0.44 [0.23, 0.52]	0.34 [0.27, 0.61]	0.85
ANG IV/ANG (1–7)	0.50 [0.33, 0.70]	0.56 [0.37, 0.85]	0.49
Perindoprilat pretreatment
ANG II/ANG (1–9)	0.87 [0.64, 1.07]	0.43 [0.30, 0.81]	0.08
ANG II/ANG (1–7)	1.03 [0.94, 1.09]	0.72 [0.70, 0.95]	0.06
ANG III/ANG (1–9)	1.00 [0.73, 1.11]	0.45 [0.37, 1.05]	0.08
ANG III/ANG (1–7)	1.18 [1.08, 1.34]	0.92 [0.90, 1.16]	0.02
ANG IV/ANG (1–9)	0.37 [0.29, 0.50]	0.16 [0.12, 0.36]	0.04
ANG IV/ANG (1–7)	0.50 [0.36, 0.53]	0.34 [0.24, 0.36]	0.02
Thiorphan pretreatment
ANG II/ANG (1–9)	1.50 [0.99, 1.99]	1.22 [0.66, 1.84]	0.41
ANG II/ANG (1–7)	2.23 [1.69, 2.32]	1.31 [1.10, 2.00]	0.08
ANG III/ANG (1–9)	1.15 [0.80, 2.39]	1.03 [0.76, 1.29]	0.28
ANG III/ANG (1–7)	1.40 [1.29, 1.77]	0.98 [0.97, 1.20]	0.02
ANG IV/ANG (1–9)	0.43 [0.24, 0.52]	0.30 [0.15, 0.53]	0.65
ANG IV/ANG (1–7)	0.45 [0.35, 0.67]	0.35 [0.27, 0.47]	0.14