Small Mouse Islets Are Deficient in Glucagon-Producing Alpha Cells but Rich in Somatostatin-Secreting Delta Cells

Figure 4

Effects of 100 nM somatostatin on the cytoplasmic Ca²⁺ concentration in one big and two small islets after elevation of glucose in the presence of 1 mM tolbutamide. Exposure to somatostatin resulted in glucose-dependent oscillations mediated by periodic interruption of elevated Ca²⁺ in 42 of 47 of the small islets and in 4 of 13 of the big islets.