Myocardial Perfusion and Function Are Distinctly Altered by Sevoflurane Anesthesia in Diet-Induced Prediabetic Rats

Table 1

Characteristics after 8 weeks of diet feeding.

	Control diet	Western diet
Caloric intake (kcal/100 gBW)	124 ± 6	129 ± 7
Blood/plasma characteristics ()
6 h fasting plasma glucose (mmol/L)	8.6 ± 0.7	10.7 ± 1.1
6 h fasting plasma insulin (pmol/L)	933 ± 383	1524 ± 353
6 h fasting plasma free fatty acids (mmol/L)	0.26 ± 0.10	0.46 ± 0.24
6 h fasting plasma triglycerides (mmol/L)	0.68 ± 0.18	3.33 ± 1.19
6 h fasting plasma HDL cholesterol (mg/dL)	112.3 ± 11.8	61.9 ± 6.7
6 h fasting plasma LDL/VLDL cholesterol (mg/dL)	15.6 ± 2.2	27.3 ± 7.0
Hematocrit (%)	50.7 ± 3.0	47.9 ± 2.2
Body composition ()
Body weight (g)	410 ± 27	478 ± 25
Heart weight (g)	1.19 ± 0.06	1.34 ± 0.15
Liver weight (g)	10.7 ± 1.0	14.2 ± 1.0
Epididymal fat weight (g)	6.0 ± 0.8	11.4 ± 2.1
Perirenal fat weight (g)	8.0 ± 1.5	16.7 ± 3.8
Tibia length (mm)	42.0 ± 0.5	41.8 ± 1.0
Hemodynamics ()
Heart rate (bpm)	405 ± 36	393 ± 48
Systolic blood pressure (mmHg)	145 ± 26	144 ± 31
Diastolic blood pressure (mmHg)	117 ± 21	116 ± 26
Mean arterial pressure (mmHg)	126 ± 22	125 ± 27

Data are mean ± SD, = 8–18; versus control diet.