Effects of the New Aldose Reductase Inhibitor Benzofuroxane Derivative BF-5m on High Glucose Induced Prolongation of Cardiac QT Interval and Increase of Coronary Perfusion Pressure

Figure 2

(a) Cardiac QT interval in hearts of Sprague-Dawley rats perfused for two hours in a Langendorff apparatus with Krebs solution containing D-glucose 11.1 mM (control); glucose 11.1 mM + DMSO 1% (vehicle); glucose 33.3 mM (high glu); high glu + BF-5m (0.01, 0.05, and 0.1 μM); high glu + BF-5m (0.1 μM) + EX527 (10 mg/kg/day i.p.). (b) Coronary perfusion pressure (CPP) recorded on a Power Lab system following exposure of perfused hearts to the same treatments as in panel (a). Values are expressed as the mean of 10 observations ± s.e.m. Significant differences versus control are reported as and ; significant differences versus high glu are reported as and ; significant differences versus high glu + BF-5m 0.1 μM are reported as ^#.

(a)

(b)