|
Ingenuity canonical pathway | OVE versus FVB | OVE-ACKR2 versus FVB |
value | Ratio | value | Ratio |
|
Diseases-specific pathways | | | | |
Hepatic fibrosis | | 26/147 | 0.003 | 6/147 |
Atherosclerosis signaling | | 23/129 | NS | 2/129 |
Altered T cell and B cell signaling in rheumatoid arthritis | | 17/92 | NS | 1/92 |
Graft-versus-host disease signaling | | 10/50 | NS | 1/50 |
Glioma invasiveness signaling | | 12/60 | NS | 1/60 |
Cellular immune response | | | | |
Communication between innate and adaptive immune cells | | 18/109 | NS | 1/109 |
Dendritic cell maturation | | 23/185 | NS | 0 |
Altered T cell and B cell signaling in rheumatoid arthritis | | 17/92 | NS | 1/92 |
Pattern recognition receptors of bacteria and viruses | | 19/106 | NS | 2/106 |
Leukocyte extravasation signaling | | 27/199 | NS | 2/199 |
Humoral immune response | | | | |
Complement system | | 13/35 | NS | 1/35 |
B cell development | | 8/36 | NS | 0 |
NF-κB signaling | | 19/175 | NS | 0 |
p38 MAPK signaling | | 14/106 | NS | 0 |
Antigen presentation pathway | | 7/40 | NS | 0 |
Intracellular and second messenger signaling | | | | |
p38 MAPK signaling | | 14/106 | NS | 0 |
Role of NFAT in regulation of the immune response | | 16/198 | NS | 0 |
Nitrogen metabolism | | 6/120 | NS | 1/120 |
Histidine metabolism | | 7/112 | 0.00012 | 5/112 |
Arginine and proline metabolism | | 8/176 | 0.00676 | 4/176 |
Cellular stress and injury | | | | |
Intrinsic prothrombin activation pathway | | 8/32 | NS | 1/32 |
Coagulation system | | 9/38 | NS | 0 |
Extrinsic prothrombin activation pathway | | 6/20 | NS | 0 |
p38 MAPK signaling | | 14/106 | NS | 0 |
HMGB1 signaling | | 11/100 | NS | 0 |
Cytokine signaling | | | | |
Dendritic cell maturation | | 23/185 | NS | 0 |
Acute phase response signaling | | 25/177 | 0.00813 | 6/177 |
TREM1 signaling | | 10/66 | NS | 0 |
IL-8 signaling | | 20/193 | NS | 2/193 |
NF-κB signaling | | 19/175 | NS | 0 |
Pathogen-influenced signaling | | | | |
Dendritic cell maturation | | 23/185 | NS | 0 |
Pattern recognition receptors of bacteria and viruses | | 19/106 | NS | 2/106 |
Virus entry via endocytic pathways | 0.00014 | 13/100 | NS | 2/100 |
Clathrin-mediated endocytosis signaling | 0.00019 | 20/195 | NS | 2/195 |
Caveolar-mediated endocytosis signaling | 0.0015 | 10/85 | NS | 1/85 |
Nuclear receptor signaling | | | | |
LXR/RXR activation | | 28/136 | 0.0002 | 7/136 |
TR/RXR activation | 0.0017 | 11/96 | NS | 2/96 |
Aryl hydrocarbon receptor signaling | 0.0028 | 14/159 | NS | 6/159 |
Nitrogen metabolism | 0.0037 | 6/120 | NS | 1/120 |
LPS/IL-1 mediated inhibition of RXR function | 0.0039 | 18/235 | NS | 9/235 |
|