Variations in the Obesity Gene “LEPR” Contribute to Risk of Type 2 Diabetes Mellitus: Evidence from a Meta-Analysis

Table 2

Pooled analyses on the association of LEPR gene polymorphisms with T2DM.

Polymorphism	Cases/controls	Genetic model	OR (95% CI)	value	(%)
p.Arg223Gln; (R223Q)	3649/2381	Allele	1.27 [1.13, 1.42]	<0.0001	38	0.13
		Dominant	1.19 [1.05, 1.35]	0.007	28	0.13
		Homozygote	1.82 [1.38, 2.39]	<0.0001	17	0.22
		Recessive	1.75 [1.35, 2.28]	<0.0001	37	0.29
p.Arg109Lys; (R109K)	3536/2268	Allele	1.02 [0.92, 1.12]	0.73	0	0.45
		Dominant	1.02 [0.86, 1.20]	0.86	27	0.23
		Homozygote	1.15 [0.81, 1.65]	0.44	0	0.8
		Recessive	1.17 [0.82, 1.66]	0.39	0	0.84
p.Lys656Asn; (K656N)	2018/1641	Allele	1.08 [0.91, 1.30]	0.38	20	0.26
		Dominant	1.09 [0.90, 1.33]	0.36	10	0.35
		Homozygote	0.79 [0.38, 1.65]	0.53	0	0.79
		Recessive	0.78 [0.38, 1.61]	0.5	0	0.83
p.Pro1019Pro; (P1019P)	753/767	Allele	1.49 [0.89, 2.50]	0.13	78	0.03
		Dominant	1.28 [0.84, 1.96]	0.25	67	0.05
		Homozygote	1.86 [1.14, 3.02]	0.01	10	0.29
		Recessive	1.75 [1.12, 2.72]	0.01	1	0.31
3′UTR; ins/del	544/690	Allele	0.69 [0.55, 0.86]	0.001	0	0.5
		Dominant	0.71 [0.55, 0.92]	0.008	34	0.22
		Homozygote	0.75 [0.05, 11.7]	0.84	66	0.08
		Recessive	0.35 [0.16, 0.76]	0.92	69	0.07