The Four-Herb Chinese Medicine Formula Tuo-Li-Xiao-Du-San Accelerates Cutaneous Wound Healing in Streptozotocin-Induced Diabetic Rats through Reducing Inflammation and Increasing Angiogenesis

Figure 2

TLXDS treatment accelerated wound healing in diabetic rats. Percentage of wound closure (mean ± SEM) of 10 mm punch biopsies was monitored every other day until day 14 (a, b). Healing of diabetic wounds was significantly delayed compared with nondiabetic wounds at all observation time points (). TLXDS began to significantly improve wound closure on day 4 (). At the end of observation (14 days), 86.8% of the wounding area healed in DM + TLXDS group, while the closure rate in DM group was only 61.6%. (c) Typical photographs of wound healing for each group. , compared with NC group, and , compared with DM group. for each group at each monitored time point.

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