Fyn Mediates High Glucose-Induced Actin Cytoskeleton Reorganization of Podocytes via Promoting ROCK Activation In Vitro

Figure 9

F-actin and paxillin expression by immunofluorescence. Under low glucose conditions (column 1), paxillin phosphorylation was undetectable and F-actin was distributed along the cell axis. After 48 hours of 30 mM glucose stimulation (column 2), the activation of paxillin was markedly upregulated with F-actin expressed at the cortical regions of the podocytes. Magnification: 400x.