CCL2 Serum Levels and Adiposity Are Associated with the Polymorphic Phenotypes -2518A on CCL2 and 64ILE on CCR2 in a Mexican Population with Insulin Resistance

Table 5

(a) Distribution of G-2518A polymorphism in CCL2 gene in other populations. (b) Distribution of Val64Ile polymorphism in CCR2 gene in other populations.

(a)

Author	Population		G	A	G/G	A/G	A/A	P
The present study	Mexican-Mestizo	380	45.2	54.6	20.7	48.9	30.3	—
Vázquez-Lavista et al. [41]	Mexican-Mestizo	126	57.5	42.5	29.4	56.3	14.3	<0.001
González-Enríquez et al. [42]	Mexican-Mestizo	21	52.4	47.6	27.0	50.0	23.0	0.370
Bektas-Kayhan et al. [24]	Caucasian	140	16.8	83.2	0.8	32.1	67.1	<0.001
Kruszyna et al. [43]	Caucasian	323	29.9	70.1	7.4	44.9	47.7	<0.001
Kucukgergin et al. [44]	Caucasian	197	30.2	69.8	9.1	42.1	48.7	<0.001
Kouyama et al. [13]	Asian	361	34.6	65.4	—	—	—	—
Singh et al. [7]	Asian	200	35.3	64.7	11.0	48.5	40.5	<0.001
Mandal et al. [45]	Asian	390	37.2	62.8	13.2	48.0	38.8	0.001
Chen et al. [23]	Asian	344	51.7	48.3	26.7	50.0	23.3	0.015
Wu et al. [46]	Asian	253	60.1	39.1	34.8	52.2	13.0	<0.001

Pearson’s goodness-of-fit test or Fishers’ exact test with significantly, comparing alleles and/or genotypes polymorphism distribution in Mexican-Mestizos population in this study versus distribution in other populations. G wild-type allele, A polymorphic allele.

(b)

Author	Population		Val	Ile	Val/Val	Val/Ile	Ile/Ile
The present study	Mexican-Mestizo	380	78.8	21.2	63.2	31.3	5.5	—
Vázquez-Lavista et al. [41]	Mexican-Mestizo	126	75.8	24.2	58.7	34.1	7.2	0.330
González-Enríquez et al. [42]	Mexican-Mestizo	21	90.5	9.5	82.6	17.3	0	0.006
Bektas-Kayhan et al. [24]	Caucasians	140	88.5	11.42	80.0	17.1	2.9	<0.001
Kucukgergin et al. [44]	Caucasians	197	89.6	10.4	80.7	17.8	1.5	<0.001
González et al. [47]	Caucasians	280	90.0	10.0	80.0	19.0	1.0	<0.001
Mandal et al. [45]	Asian	390	74.4	25.6	54.8	39.2	6.0	0.046
Wu et al. [46]	Asian	253	80.6	19.4	64.4	32.4	3.2	0.438
Singh et al. [7]	Asian	200	80.5	19.5	63.0	35.0	2.0	0.501
Zandifar et al. [48]	Asian	100	87.5	12.5	75.0	25.0	0	0.007
Chen et al. [23]	Asian	344	89.1	10.9	80.2	17.7	2.1	<0.001

Pearson’s goodness-of-fit test or Fishers’ exact test with significantly, comparing alleles and/or genotypes polymorphism distribution in Mexican-Mestizos population in this study versus distribution in other populations. Val: wild-type allele; Ile: polymorphic allele.