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Journal of Diabetes Research
Volume 2016, Article ID 6194750, 9 pages
http://dx.doi.org/10.1155/2016/6194750
Research Article

Circulating Betatrophin in Patients with Type 2 Diabetes: A Meta-Analysis

1Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China
2Chinese Evidence-Based Medicine Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China
3Department of Endocrinology and Metabolism, The Third People’s Hospital of Chengdu, Chengdu, Sichuan 610031, China
4Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, No. 37 Guoxue Road, Chengdu, Sichuan 610041, China

Received 16 April 2015; Revised 12 June 2015; Accepted 15 June 2015

Academic Editor: Raffaele Marfella

Copyright © 2016 Sheyu Li et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective. To investigate the association between circulating betatrophin level and type 2 diabetes mellitus (T2DM) in human. Methods. A comprehensive literature search was performed in PubMed and Embase databases to identify eligible studies assessing the circulating levels of betatrophin in both T2DM patients and nondiabetic adults. Results. A total of nine eligible studies with twelve comparisons were included for the final meta-analysis. Circulating betatrophin levels in T2DM patients were higher than those in the nondiabetic controls (random-effect SMD 0.53; 95% CI 0.13 to 0.94; ). In the subgroup of nonobese population but not the obese population, the overall betatrophin level in T2DM patients was much higher than that in the nondiabetic controls (nonobese: random-effect SMD, 0.82; 95% CI 0.42 to 1.21; ; obese: random-effect SMD, −0.39; 95% CI, −0.95 to 0.18; ). Metaregression indicated that body mass index of T2DM patients was associated with mean difference of betatrophin level between T2DM and nondiabetic adults (slope, −578.8; ; ). Conclusion. Based on the findings of our meta-analysis, circulating betatrophin level of T2DM patients is higher than that of nondiabetic adults in the nonobese population, but not in the obese population.