Comparison of the Current Diagnostic Criterion of HbA1c with Fasting and 2-Hour Plasma Glucose Concentration

Table 6

Performance of HbA1c on the diagnosis of diabetes in reference to fasting and 2-hour plasma glucose.

	Fasting plasma glucose	Two-hour plasma glucose
Sensitivity	43.3%	28.1%
Specificity	99.3%	99.3%
Positive predictive value	72.6%	75.3%
Negative predictive value	97.5%	95.0%
False positive rate	0.7%	0.7%
False negative rate	56.7%	71.9%
ROC area under curve (95% CI)	0.871 (0.842, 0.899)	0.816 (0.791, 0.841)
Cohen’s kappa coefficient (95% CI)	0.527 (0.467, 0.588)	0.386 (0.334, 0.439)