Research Article

Transcriptome Profiles Using Next-Generation Sequencing Reveal Liver Changes in the Early Stage of Diabetes in Tree Shrew (Tupaia belangeri chinensis)

Table 2

Genes differentially expressed in liver tissues of tree shrew.

IDGene nameGene symbolFold changesBiological processKEGG pathway

XLOC_001420Acetyl coenzyme A acyltransferase 2Acaa2(−) 8.01Metabolic process hsa00062:Fatty acid elongation in mitochondria
TSDBG00010707Beta-2-adrenergic receptorAdrb2(+) 4.61G-protein coupled receptor signaling pathway
TSDBG00019059Angiotensin II receptor, type 2Agtr2(+) 693.72G-protein coupled receptor signaling pathway
TSDBG00005129Aldo-keto reductase family 1, member B1Akr1b1(+) 6.08Electron transport
TSDBG00003625Beta-2-microglobulinB2m(−) 4.58Immune response
TSDBG00006817Beta-2-bradykinin receptorBdkrb2(+) 8.08Transport
TSDBG00021527Calneuron 1Caln1(+) 18.60NA
TSDBG00019726Cadherin 3Cdh3(+) 85.20Cytoskeleton
TSDBG00017230Chromogranin AChga(+) 47.78Regulation of blood pressure
TSDBG00004640Chromogranin BChgb(+) 84.21Signal transduction
TSDBG00013910Cytochrome c oxidase subunit VACox5a(−) 8.05Electron transport
TSDBG00011477Cytochrome c oxidase subunit VBCox5b(−) 11.26Electron transport
TSDBG00013437Cytochrome c oxidase subunit VIcCox6c(−) 5.81Electron transport
TSDBG00018314C-reactive proteinCrp(+) 5.86Inflammatory response
TSDBG00007703Chemokine (C-X-C motif) ligand 13Cxcl13(−) 10.59Immune response
TSDBG00022385Cytochrome P450, family 11, subfamily A, polypeptide 1Cyp11a1(+) 71.64Electron responsehsa00140:Steroid hormone biosynthesis
TSDBG00016058Cytochrome P450, family 11, subfamily B, polypeptide 2Cyp11b2(+) 76.51Electron responsehsa00141:Steroid hormone biosynthesis
TSDBG00016058Cytochrome P450, family 11, subfamily B, polypeptide 2Cyp11b2(+) 68.25Electron responsehsa00143:Steroid hormone biosynthesis
TSDBG00016479Cytochrome P450, family 17, subfamily A, polypeptide 1Cyp17a1(+) 95.77Electron responsehsa00144:Steroid hormone biosynthesis
TSDBG00010507Cytochrome P450, family 7, subfamily A, polypeptide 1Cyp7a1(+) 5.74Electron responsehsa00144:Steroid hormone biosynthesis
XLOC_008932Dynein, light chain, LC8-type 1Dynll1(−) 14.05Cytoskeleton
TSDBG00020294Enoyl CoA hydratase, short chain, 1,Echs1(−) 19.90Metabolic process hsa00062:Fatty acid elongation in mitochondria
TSDBG00018541Eukaryotic translation elongation factor 1 alpha 1Eef1a1(−) 5.15Macromolecular turnover
XLOC_007804Ferritin, heavy chain, polypeptide 1Fth1(−) 12.76Metabolic process
TSDBG00003452G0/G1 switch 2G0s2(−) 26.68Signal transduction
TSDBG00020849Glial cell derived neurotrophic factorGdnf(+) 273.86Signal transduction
TSDBG00001160Hemoglobin, alpha 1Hba1(−) 6.70Transport
TSDBG00005453Hemoglobin, betaHbb(+) 11.90Transport
TSDBG00021208High mobility group nucleosome binding domain 1Hmgn1(−) 15.39Cytoskeleton
XLOC_002257Heat shock protein 1Hspd1(−) 5.54Other
TSDBG00002459Kruppel-like factor 6Klf6(+) 4.90Macromolecular turnover
TSDBG00018913Leukocyte cell-derived chemotaxin 2Lect2(−) 19.18Immune response
TSDBG00013095Lysozyme Lyz(−) 10.04Metabolic process
TSDBG00002162Melanocortin 2 receptorMc2r(+) 116.92G-protein coupled receptor signaling pathway
TSDBG00024122Mitochondrially encoded ATP synthase 6MT-Atp6(−) 187.11Metabolic process
TSDBG00024207Mitochondrially encoded cytochrome c oxidase IMt-co1(−)Metabolic process
TSDBG00024123Mitochondrially encoded cytochrome c oxidase IIIMt-co3(−)Metabolic process
TSDBG00024119Mitochondrially encoded NADH dehydrogenase 4Mt-nd4(−)Metabolic process
TSDBG00013867Myomesin 1Myom1(−) 9.47Muscle contraction
TSDBG00014996NucleolinNcl(−) 22.79NA
XLOC_009534Nucleolar protein interacting with the FHA domain of MKI67Nifk(−) 20.77Macromolecular turnover
XLOC_009785Nucleophosmin 1Npm1(−) 23.49Signal transduction
TSDBG00009363Nuclear receptor subfamily 5, group A, member 1Nr5a1(+) 31.23Translation
XLOC_007808Poly(rC) binding protein 2Pcbp2(−) 5.67Immune response
XLOC_008508Peroxiredoxin 1Prdx1(−) 4.40Response to ROS
TSDBG00020861Prolactin receptorPrlr(+) 8.54Metabolic process
TSDBG00023696Prostate stem cell antigenPsca(−) 6.50NA
TSDBG00017201Proteasome (prosome, macropain) subunit, alpha type, 6Psma6(−) 17.58Other
XLOC_00888918S ribosomal RNARn18s(−) 8.17NA
XLOC_008890RNA, 45S pre-ribosomal 5Rna45s5(−) 6.86NA
TSDBG00008648Reactive oxygen species modulator 1Romo1(−) 3.84Response to ROS
TSDBG00000016Ribosomal protein L21Rpl21(−) 16.72Translation hsa03013:Ribosome
TSDBG00015118Ribosomal protein L21Rpl21(−) 13.55Translationhsa03013:Ribosome
TSDBG00021103Ribosomal protein L21Rpl21(−) 14.86Translationhsa03013:Ribosome
TSDBG00010811Ribosomal protein L21Rpl21(−) 78.98Translationhsa03013:Ribosome
TSDBG00013239Ribosomal protein L21Rpl21(−) 8.21Translationhsa03013:Ribosome
TSDBG00008910Ribosomal protein L22Rpl22(−) 5.38Translationhsa03013:Ribosome
TSDBG00013442Ribosomal protein L30Rpl30(−) 5.32Translationhsa03013:Ribosome
XLOC_009108Ribosomal protein L31Rpl31(−) 11.86Translationhsa03013:Ribosome
TSDBG00008508Ribosomal protein L34Rpl34(−) 100.22Translationhsa03013:Ribosome
XLOC_006890Ribosomal protein L35aRpl35a(−) 16.94Translationhsa03013:Ribosome
TSDBG00016157Ribosomal protein L4Rpl4(−) 8.55Translationhsa03013:Ribosome
TSDBG00001838Ribosomal protein S24Rps24(−) 4.50Translationhsa03013:Ribosome
TSDBG00006238Ribosomal protein S24Rps24(−) 14.75Translationhsa03013:Ribosome
TSDBG00013032Ribosomal protein S26Rps26(−) 5.76Translationhsa03013:Ribosome
XLOC_003904Methylsterol monooxygenase 1Sc4mol(−) 4.43Metabolic process
TSDBG00006015Secretogranin IIScg2(+) 156.25Signal transduction
TSDBG00002295Secretoglobin, family 2A, member 2Scgb2a2(−) 138.70NA
XLOC_008362Small ubiquitin-like modifier 1Sumo1(−) 16.29Regulation of cell proliferation
TSDBG00017904Trefoil factor 3Tff3(−) 15.12Immune response
XLOC_010510Translocase of inner mitochondrial membrane 13Timm13(−) 5.71Transport
TSDBG00009988Transmembrane protein 252Tmem252(+) 5.85NA
XLOC_004969Ubiquitin-conjugating enzyme E2D 2AUbe2d2a(−) 6.67Other
TSDBG00019547Vestigial-like family member 3Vgll3(+) 17.36Macromolecular turnover
XLOC_003709VimentinVim(−) 13.65Regulation of cell proliferation
TSDBG00009142WAP four-disulfide core domain 2Wfdc2(+) 8.18Proteolysis

Diabetic group/control group; (+): upregulated; (−): downregulated.