Transcriptome Profiles Using Next-Generation Sequencing Reveal Liver Changes in the Early Stage of Diabetes in Tree Shrew (Tupaia belangeri chinensis)

Table 3

Biological processes and genes likely affected among tree shrews with STZ-induced diabetes.

Function	Genes	value
Translational process	RPL35A, RPS26, EEF1A1, RPL30, RPL31, RPL22, RPL34, RPL21, RPL4, RPS24
Regulation of blood pressure	ADRB2, AGTR2, CHGA, CYP11B2, BDKRB2, HBB
Steroid metabolic process	ACAA2, CYP17A1, PRLR, CYP11A1, CYP7A1, CYP11B2, SC4MOL
Mitochondrion	ACAA2, CYP11A1, CYP11B2, ECHS1, ROMO1, TIMM13, COX5A, COX5B, PRDX1, COX6C, CYP17A1, PSMA6, HSPD1, MTCO1, MTCO3, MTND4, MTATP6	0.0019
Electron carrier activity	CYP7A1, CYP17A1, CYP11A1, CYP11B2, AKR1B1, COX5A	0.0019
Oxidation reduction	CYP7A1, CYP17A1, CYP11A1, CYP11B2, AKR1B1, COX5A, PRDX1, FTH1, SC4MOL, AGTR2, GDNF	0.0036
Regulation of apoptosis	ADRB2, AGTR2, PRLR, DYNLL1, NPM1, BDKRB2, HSPD1, GDNF, PRDX1, SCG2	0.0042
Cytochrome c oxidase activity	COX5A, COX5B, COX6C	0.0056
Lipid biosynthetic process	ACAA2, CYP17A1, PRLR, CYP11A1, CYP11B2, SC4MOL	0.0091
Steroid binding	CYP11A1, CYP11B2, SCGB2A2	0.027
Response to reactive oxygen species	CYP11A1, ROMO1, PRDX1	0.036
Inflammatory response	CXCL13, CRP, LYZ, BDKRB2, SCG2	0.040
Fatty acid elongation in mitochondria	ACAA2, ECHS1	0.046