Genetic Analysis and Follow-Up of 25 Neonatal Diabetes Mellitus Patients in China

Table 1

Clinical characteristics of NDM patients.

	NDM	PNDM	TNDM
Cases	25	18	7
Male (female)	14 (11)	11 (7)	3 (4)^#
Birth weight; (kg, mean ± SD)	2.6 ± 0.5	2.7 ± 0.5	2.4 ± 0.6^#
Age at diagnosis; (Days, mean ± SD)	74.4 ± 41.4	81.3 ± 42.7	56.7 ± 34.6^#
DK/DKA (%)	68.0%	77.8%	42.9%^#
Symptoms; (cases)		Infection (6); Decreased responsiveness (5); Polydipsia, polyuria (2); Urine sticky (4); Seizures (2)	Infection (4); Polydipsia, polyuria (1); Seizures (2)
Physical development on follow-up (cases)		Physical and mental retardation (4), others are normal	Intellectual and physical development is normal
Genetic testing (cases)		KCNJ11 (5); ABCC8 (1); INS (1); EIF2AK3 (3); SLC19A2 (1); GLIS3 (1)	ABCC8 (2); Paternal uniparental disomy of 6q24 (1)
Therapy (cases)		Glyburide (3); Insulin (15)	Remission in 2 weeks to 1 year after insulin therapy (6)
Average HbA1c at the last follow-up (cases had recorded results)		7.2% (15)	5.5% (5)

^#No significant differences compared with PNDM ().