Coenzyme Q10 Attenuates High Glucose-Induced Endothelial Progenitor Cell Dysfunction through AMP-Activated Protein Kinase Pathways

Figure 6

Effect of CoQ10-treated EPCs in high glucose medium transplantation on hindlimb perfusion. (a) Serial laser Doppler analyses of hindlimb perfusion revealed before and 3 weeks after hindlimb ischemia surgery in nude mice, which received a transplant with normal saline, EPCs, high glucose-treated EPCs, and high glucose-treated EPC incubated with CoQ10. Low or no perfusion is displayed as blue, whereas the highest perfusion is displayed as red. Arrows indicate ischemic (right) limb after hindlimb ischemia surgery. (b) Quantification analysis of perfusion recovery by laser Doppler perfusion imaging rations (ischemic/normal hindlimb) over time in the different groups. Results are mean ± SE; ; versus control (5 mM glucose); versus high glucose (HG).

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