Research Article
Lack of Association between SLC30A8 Variants and Type 2 Diabetes in Mexican American Families
Table 4
Gene burden test for the association of the SLC30A8 locus with T2D-related traits.
| Trait | Based on all 118 SNPs | Based on 2 coding SNPs | Based on 11 MSA SNPs | | SE | | | SE | | | SE | |
| Ever T2D | 0.0000 | 0.0000 | 1.0000 | 0.0005 | 0.0028 | 0.8498 | 0.0080 | 0.0112 | 0.4774 | Incident T2D | 0.0000 | 0.0000 | 1.0000 | 0.0010 | 0.0052 | 0.8413 | 0.0192 | 0.0223 | 0.3902 | Fasting glucose | 0.0000 | 0.0000 | 1.0000 | 0.0000 | 0.0000 | 1.0000 | 0.0047 | 0.0055 | 0.3946 | Fasting insulin | 0.0000 | 0.0000 | 1.0000 | 0.0000 | 0.0000 | 1.0000 | 0.0031 | 0.0043 | 0.4720 | 2-hour glucose | 0.0093 | 0.0101 | 0.3600 | 0.0006 | 0.0023 | 0.8055 | 0.0039 | 0.0055 | 0.4804 | 2-hour insulin | 0.0037 | 0.0067 | 0.5791 | 0.0000 | 0.0000 | 1.0000 | 0.0021 | 0.0043 | 0.6288 | HOMA-IR | 0.0000 | 0.0000 | 1.0000 | 0.0000 | 0.0000 | 1.0000 | 0.0044 | 0.0051 | 0.3898 | HOMA-β | 0.0000 | 0.0000 | 1.0000 | 0.0000 | 0.0000 | 1.0000 | 0.0057 | 0.0057 | 0.4102 |
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