Impaired Thermogenesis and a Molecular Signature for Brown Adipose Tissue in Id2 Null Mice

Table 1

Differentially expressed genes from insulin signaling pathway of Id2−/− mice. Genes with significant differences () are shown in bold. Peak phase value (determined by Lomb-Scargle phase values within CIRCA) in circadian time (CT) is provided where gene was identified as a clock control gene. Rhythmic genes identified from CIRCA database of Mouse 1.OST Brown Adipose (Affymetrix).

Insulin signaling array	Symbol	Refseq	All		Male		Female		Clock control gene-peak phase
			Fold change	value	Fold change	value	Fold change	value
Gene name
AE binding protein 1	Aebp1	NM_009636	1.9	0.09			1.6	0.03	—
Complement factor D (adipsin)	Cfd	NM_013459	2.4	0.01	3.6	0.03			—
Fructose bisphosphatase 1	Fbp1	NM_019395	1.3	0.22			1.6	0.05	—
Glucose-6-phosphatase, catalytic	G6pc	NM_008061	1.5	0.28	1.5	0.33	1.6	0.02	—
Growth factor receptor bound protein 10	Grb10	NM_010345	1.5	0.08					—
Insulin receptor substrate 1	Irs1	NM_010570	1.4	0.01	1.3	0.07	1.4	0.05	—
Protein tyrosine phosphatase, receptor type, F	Ptprf	NM_011213	1.7	0.05			2.6	0.05	—
Scr homology 2 domain containing transforming protein C1	Shc1	NM_011368					1.25	0.01	—
Glucose-6-phosphatase, catalytic, 2	G6pc2	NM_021331			−3.2	0.08			—
Insulin-like growth factor 2	Igf2	NM_010514	−1.2	0.21			−1.4	0.04	—
V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	Kras	NM_021284	−1.1	0.09	−1.25	0.03			—
Protein kinase C, iota	Prkci	NM_008857	−1.2	0.02	−1.3	0.02			CT0
Thyroglobulin	Tg	NM_009375	−1.8	0.29	−3.5	0.02			—