A Molecular and Whole Body Insight of the Mechanisms Surrounding Glucose Disposal and Insulin Resistance with Hypoxic Treatment in Skeletal Muscle

Figure 2

Proposed communication between hypoxia- and insulin-stimulated glucose transport mechanisms. (a) displays the proposed hypoxia-induced Ca²⁺/CaMKK inhibition on insulin signaling and insulin-stimulated glucose transport. Glucose transport is facilitated via an AMPK-dependent mechanism in response to hypoxia despite decreased Akt activity. (b) Glucose transport mechanisms in response to insulin. (b) also displays Akt mediated AMPK phosphorylation at Ser^485/491 [93] resulting in AMPK inhibition.

(a)

(b)