Altered Macrophage and Dendritic Cell Response in Mif−/− Mice Reveals a Role of Mif for Inflammatory-Th1 Response in Type 1 Diabetes

Figure 1

Mif−/− mice developed less severe hyperglycemia than Wt mice after type 1 diabetes mellitus induction. Blood glucose (every 2 weeks) (a) and serum insulin (0, 2,, and 8 weeks) (b) levels were monitored as described in Section 2 in Wt (■) and Mif−/− (▼) mice after STZ administration; as controls, healthy Wt (○) or healthy Mif−/− (Δ) mice were plotted as well. All data are representative of three independent experiments and are expressed as the means ± SE (n = at least 5–7 animals per group/time point). , , GraphPad Prism software 6.

(a)

(b)