New Insights from Sum Frequency Generation Vibrational Spectroscopy into the Interactions of Islet Amyloid Polypeptides with Lipid Membranes

Figure 4

The misfolding pathway of hIAPP on membrane surfaces. (a) Chiral SFG intensities of the chiral N-H stretching (3280 cm⁻¹) and amide I signals (1620 cm⁻¹) as a function of time from triplicate experiments. (b) The model mechanism on hIAPP aggregation at the membrane surface: adsorption of disordered hIAPP onto membrane leads to formation of α-helical intermediates which are then converted to β-sheet aggregates. Adapted from [61] with permission. Copyright 2011 American Chemical Society.

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