New Insights from Sum Frequency Generation Vibrational Spectroscopy into the Interactions of Islet Amyloid Polypeptides with Lipid Membranes

Figure 5

Kinetics study using AFM and SFG measurements during hIAPP aggregation at the phospholipid interface in the presence, or absence, of EGCG. AFM images of hIAPP with lipid for (a) 10 and (b) 1020 min in the absence of EGCG and (c) AFM image after hIAPP aggregation in the presence of EGCG for 1020 min. SFG spectra of hIAPP with phospholipid in the amid I region (d) in the absence of, and (e) in the presence of, EGCG. Adapted from [64] with permission. Copyright 2012 American Chemical Society.