New Insights from Sum Frequency Generation Vibrational Spectroscopy into the Interactions of Islet Amyloid Polypeptides with Lipid Membranes

Figure 8

Bilayer thickness around embedded hIAPP for (a) trimer and (b) tetramer aggregates, as described by molecular dynamics simulations. Color key: bilayer thickness (in nm) is mapped to the corresponding colors. (c) Water channel formed by the hIAPP trimer in the DPPG bilayer, showing water molecules (red and white) and Na⁺ ions (blue vdW spheres) percolating through the bilayer. (d) Average particle density of water and Na⁺ ions within the membrane. Adapted from [14] with permission. Copyright 2013 by the Biophysical Society.

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