Research Article
Taurine Transporter Gene Expression in Mononuclear Blood Cells of Type 1 Diabetes Patients
Table 1
Main characteristics of diabetic patients and control subjects.
| | | Controls | Type 1 diabetic patients | |
| | Number | 33 | 35 | | | Age (yr) | 41 ± 11 | 44 ± 12 | NS | | Sex (M/F) | 12/21 | 18/17 | NS | | BMI (Kg/m2) | 23.9 ± 3.3 | 25.2 ± 4.1 | NS | | Duration of diabetes (yr) | — | 23.13 ± 9.44 | — | | Plasma glucose (mmol/L) | 5.32 ± 0.48 | 8.29 ± 3.27 | 0.0001 | | HbA1c (%, mmol/mol) | 5.38 ± 0.38, 34.64 ± 4.15 | 7.88 ± 1.07, 62.71 ± 11.70 | 0.0001 | | Plasma taurine (µmol/L) | 51.05 (19.30) | 47.39 (23.46) | NS | | Intracellular taurine (nmol/106 cells) | 38.33 (26.9) | 54.19 (36.87) | NS | | Plasma arginine (µmol/L) | 90.88 (19.49) | 83.71 (23.41) | NS | | Plasma homocysteine (µmol/L) | 11.4 (3.3) | 11.1 (6.1) | NS | | Asymmetric dimethylarginine (µmol/L) | 0.56 (0.22) | 0.56 (0.13) | NS | | Symmetric dimethylarginine (µmol/L) | 0.51 (0.28) | 0.51 (0.14) | NS | | Plasma malonyldialdehyde (µmol/L) | 3.55 (2.14) | 4.47 (1.68) | NS | | Intracellular carbonyls (nmol/mg) | 1.37 (0.82) | 1.30 (0.56) | NS | | Lymphocytes (106 cells/mL) | 2.60 (0.86) | 2.35 (0.79) | NS | | Monocytes (106 cells/mL) | 0.50 (0.16) | 0.45 (0.19) | NS | | TauT mRNA gene expression () | 1.00 (0.15) | 1.32 (0.31) | 0.0001 | | Urinary albumin/creatinine (μg/mg) | 5.277 (7.014) | 5.601 (6.821) | NS |
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Data are shown as median (interquartile range) or mean ± SD.
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