Topical Administration of Pirfenidone Increases Healing of Chronic Diabetic Foot Ulcers: A Randomized Crossover Study
Table 2
Baseline ulcer characteristics.
Characteristics
Total ()
Group 1 ()
Group 2 ()
Size, cm2
1.32 [0.49–6.55]
0.75 [0.40–7.56]
1.40 [1.08–3.41]
0.630
Depth
0.955
Superficial
15 (42.9)
9 (42.9)
6 (42.9)
Dermis, muscle, tendon
18 (51.4)
11 (52.4)
7 (50.0)
All layers
2 (5.7)
1 (4.8)
1 (7.1)
ABI right
0.406
Normal
7 (20)
5 (23.8)
2 (14.3)
Noncompressible
28 (80)
16 (76.2)
12 (85.7)
ABI left
0.003
Normal
11 (32.4)
10 (50)
1 (7.1)
PAD
3 (8.8)
3 (15)
0
Noncompressible
20 (58.8)
8 (35)
13 (92.9)
Depth
0.970
Superficial
15 (41.6)
9 (40.9)
6 (42.9)
Dermis, muscle, tendon
18 (50)
11 (50)
7 (50)
All layers
3 (8.3)
2 (9.1)
1 (7.1)
Data expressed in median [interquartile range] or number (percentage). ABI: ankle brachial index; PAD: peripheral arterial disease. ABI was classified as follows: normal from >0.9–1.3, ≤0.9 PAD, <0.4 severe PAD, and >1.3 noncompressible vessel [11]. In one patient left ABI could not be estimated due to history of amputation.
