Oxygenation of the Intraportally Transplanted Pancreatic Islet

Figure 3

Surface plots illustrating model results for four different cases in which the Baseline Case (no thrombus, OCR/DNA = 200 nmol/min/mg DNA,  mm Hg, and -μm) is perturbed by adjusting only 1 of the 4 parameters with each case. Case A depicts the Baseline Case with an increase in the islet diameter from 150 to 300 μm. Case B depicts the Baseline Case with an increase in the OCR/DNA from 200 to 300 nmol/min/mg DNA. Case C depicts the Baseline Case with a decrease in from 15 to 5 mm Hg. Case D depicts the Baseline Case with the addition of a 100 μm thrombus on the proximal half-surface of the islet. The anoxic volume fraction (AVF) is depicted by the achromatic core. Note the magnitude of the AVF associated with each perturbation. AVF, anoxic volume fraction; OCR, oxygen consumption rate; , oxygen partial pressure; , external blood ; , islet radius.