Oxygenation of the Intraportally Transplanted Pancreatic Islet

Figure 5

Graphs depicting a summary of model results for calculation of anoxic volume fraction [AVF (%)] with respect to external blood (), islet fractional viability (OCR/DNA), and diameter () and with or without thrombus formation ( μm). The graph on the left (a) illustrates the change in AVF for an islet of average diameter (150 μm) for the 3 OCR/DNA values. The graph on the right (b) illustrates the change in AVF in an islet with average OCR/DNA (200 nmol/min/mg DNA) for 3 islet diameter values. AVF is defined as the region of the islet that is anoxic, occurring below a critical () of 0.1 mm Hg. AVF, anoxic volume fraction; , thickness of the thrombus; OCR, oxygen consumption rate; , oxygen partial pressure; , critical for viability; , external blood ; , islet radius.

(a)

(b)