Oxygenation of the Intraportally Transplanted Pancreatic Islet

Table 1

Summary of model parameters.

Description	Formulaic abbreviation	Prescribed value(s)	Units	Reference(s)
Oxygen permeability
Islet			mol/cm/mm Hg/sec	[34, 35]
Thrombus			mol/cm/mm Hg/sec	[36]
Oxygen supply
External blood		5–40	mm Hg	[33]
Oxygen threshold
Critical (viability)		0.1	mm Hg	[37, 38]
Critical (function)		5–15	mm Hg	[31, 34, 39–41]
Fractional viability
Islet	OCR/DNA	100–300	nmol/min/mg DNA	[42–44]
Size/thickness
Islet diameter		100–300	µm	—
Thrombus thickness		100	µm	[45–48]
Other
Michaelis-Menten constant (islet OCR)		0.44	mm Hg	[39]