Bioinformatic Evaluation of Transcriptional Regulation of WNT Pathway Genes with reference to Diabetic Nephropathy

Figure 4

Expression of enriched transcription factors from four independent datasets. Log₂ expression values evaluated in Nephromine (http://www.nephromine.org) from whole kidney (WK [32]) biopsies, glomerulus (Glom [33]) biopsies, tubulointerstitium (Tubulo [33]) biopsies, and from HK-2 cells treated with TGF-β for 48 hours (TGF-β [34]). MZF1 gene expression was significantly increased in diabetic nephropathy (DN) whole kidney tissue compared to non-DN control (fold change = 1.16; ). TFAP2A gene expression was decreased in HK-2 cells treated with TGF-β compared to untreated HK-2 cells (−1.02-fold change; ).