Review Article
A Systems Biology Overview on Human Diabetic Nephropathy: From Genetic Susceptibility to Post-Transcriptional and Post-Translational Modifications
Table 3
Noncoding RNA markers. Collection of noncoding RNA transcripts deregulated in DN samples. List is ordered alphabetically.
| miRNA transcript | Sample type | Expression | Assay type | Diabetes type | Potential value of biomarker | References |
| hsa-miR-1205 | Mesangial cells | Up | qPCR | — | Descriptive | [66] | hsa-miR-129 | Human mesangial cells | Up | Array/qPCR | — | — | [67] | hsa-miR-130a | Urinary exosomes | Up | qPCR | T1D | Diagnostic | [68] | hsa-miR-145 | Urinary exosomes | Up | qPCR | T1D | Diagnostic | [68] | hsa-miR-146a | Kidney | Up | Array/qPCR | T2D | Diagnostic | [69] | hsa-miR-15 | Urinary sediment | Down | qPCR | — | Diagnostic/prognostic | [70] | hsa-miR-155 | Urinary exosomes | Down | qPCR | T1D | Diagnostic/prognostic | [68] | hsa-miR-155 | Kidney | Up | Array/qPCR | T2D | Prognostic | [69] | hsa-miR-188-3p | Urine | Down | qPCR | T1D | Prognostic | [71] | hsa-miR-1913 | Urine | Up | qPCR | T1D | Prognostic | [71] | hsa-miR-192 | Kidney | Down | qPCR/ISH | — | Diagnostic/prognostic | [72] | hsa-miR-192 | Human mesangial cells | Up | Array | — | — | [67] | hsa-miR-192 | Urinary sediment | Down | qPCR | — | Diagnostic/prognostic | [73] | hsa-miR-21 | Kidney | Up | qPCR | T2D | Diagnostic | [74] | hsa-miR-214-3p | Urine | Up | qPCR | T1D | Prognostic | [71] | hsa-miR-221-3p | Urine | Down | qPCR | T1D | Prognostic | [71] | hsa-miR-29a | Urine | Up | qPCR | T2D | Prognostic | [75] | hsa-miR-323b-5p | Urine | Down | qPCR | T1D | Prognostic | [71] | hsa-miR-337 | Human mesangial cells | Up | Array/qPCR | — | — | [67] | hsa-miR-373-5p | Urine | Up | qPCR | T1D | Prognostic | [71] | hsa-miR-377 | Human mesangial cells | Up | Array/qPCR | — | — | [67] | hsa-miR-424 | Urinary exosomes | Down | qPCR | T1D | Prognostic | [68] | hsa-miR-429 | Urine | Up | qPCR | T1D | Prognostic | [71] | hsa-miR-524-5p | Urine | Down | qPCR | T1D | Prognostic | [71] | hsa-miR-638 | Urine | Up | qPCR | T1D | Prognostic | [71] | hsa-miR-765 | Urine | Up | qPCR | T1D | Prognostic | [71] | hsa-miR-92b-5p | Urine | Up | qPCR | T1D | Prognostic | [71] | let-7a | Whole blood | Down | Array/qPCR | T2D | Diagnostic | [76] | PVT1 (lncRNA) | Mesangial cells | Up | qPCR | — | Descriptive | [66] |
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