A Systems Biology Overview on Human Diabetic Nephropathy: From Genetic Susceptibility to Post-Transcriptional and Post-Translational Modifications

<table class="table-group" id="tab4"><tr><td><table class="table"><tr><td class="thead-hr" colspan="6"><hr/></td></tr><tr class="thead"><td align="left">Locus</td><td align="center">Sample type</td><td align="center">Type of modification</td><td align="center">Diabetes type</td><td align="center">Potential value of  biomarker  </td><td align="center">References</td></tr><tr><td class="thead-hr" colspan="6"><hr/></td></tr><tr><td align="left">SHC1</td><td align="center">PBMC</td><td align="center">Reduced promoter methylation</td><td align="center">—</td><td align="center">Diagnostic</td><td align="center">[<a href="/journals/jdr/2016/7934504/#B93">77</a>]</td></tr><tr><td align="left">UNC13B</td><td align="center">Whole blood</td><td align="center">Increased DNA methylation</td><td align="center">T1D</td><td align="center">Diagnostic/prognostic</td><td align="center">[<a href="/journals/jdr/2016/7934504/#B94">78</a>]</td></tr><tr class="table-tr"><td colspan="6"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

Epigenetic markers. List of epigenetic marks identified in DN. List is ordered alphabetically.

Journal of Diabetes Research

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Table 4: A Systems Biology Overview on Human Diabetic Nephropathy: From Genetic Susceptibility to Post-Transcriptional and Post-Translational Modifications 

Table 4 | A Systems Biology Overview on Human Diabetic Nephropathy: From Genetic Susceptibility to Post-Transcriptional and Post-Translational Modifications 